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AADAT Antibody (PA5-88974) in IHC (P)
Immunohistochemistry analysis of AADAT in paraffin-embedded human liver. Samples were incubated with AADAT Polyclonal antibody (Product # PA5-88974) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-88974
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 34-429 of human AADAT (NP_0012736111)
Conjugate
Form
Liquid
Concentration
1.38 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805265
Product Specific Information
Immunogen sequence: PKSMISLAGG LPNPNMFPFK TAVITVENGK TIQFGEEMMK RALQYSPSAG IPELLSWLKQ LQIKLHNPPT IHYPPSQGQM DLCVTSGSQQ GLCKVFEMII NPGDNVLLDE PAYSGTLQSL HPLGCNIINV ASDESGIVPD SLRDILSRWK PEDAKNPQKN TPKFLYTVPN GNNPTGNSLT SERKKEIYEL ARKYDFLIIE DDPYYFLQFN KFRVPTFLSM DVDGRVIRAD SFSKIISSGL RIGFLTGPKP LIERVILHIQ VSTLHPSTFN QLMISQLLHE WGEEGFMAHV DRVIDFYSNQ KDAILAAADK WLTGLAEWHV PAAGMFLWIK VKGINDVKEL IEEKAVKMGV LMLPGNAFYV DSSAPSPYLR ASFSSASPEQ MDVAFQVLAQ LIKESL; Positive Samples: Mouse liver, Rat kidney; Cellular Location: Mitochondrion
Target Information
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; AadAT; Alpha-aminoadipate aminotransferase; Glycine transaminase AADAT; KAT/AadAT; kynurenine aminotransferase 2; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; kynurenine--oxoglutarate; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; L kynurenine/alpha aminoadipate aminotransferase; Methionine--glyoxylate transaminase AADAT
Gene Aliases: AADAT; Aadt; AI875679; KAT2; KATII; KYAT2; mKat-2
UniProt ID: (Human) Q8N5Z0, (Mouse) Q9WVM8, (Rat) Q64602
Entrez Gene ID: (Human) 51166, (Mouse) 23923, (Rat) 29416
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