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Product Details
17990-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AANAT Fusion Protein Ag12422 (1-207 aa encoded by BC092430)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTQSTHPL KPEAPRLPPG IPESPSCQRR HTLPASEFRC LTPEDAVSAF EIEREAFISV LGVCPLYLDE IRHFLTLCPE LSLGWFEEGC LVAFIIGSLW DKERLMQESL TLHRSGGHIA HLHVLAVHRA FRQQGRGPIL LWRYLHHLGS QPAVRRAALM CEDALVPFYE RFSFHAVGPC AITVGSLTFM ELHCSLRGHP FLRRNSGC (1-207 aa encoded by BC092430)
Target Information
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function. Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina. Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AA-NAT; Aralkylamine N-acetyltransferase; arylakylamine N-acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; Seretonin N-acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase
Gene Aliases: AA-NAT; AANAT; DSPS; Nat-2; Nat4; SNAT
UniProt ID: (Human) Q16613, (Mouse) O88816, (Rat) Q64666
Entrez Gene ID: (Human) 15, (Mouse) 11298, (Rat) 25120
N-terminal protein amino acid acetylation
circadian rhythm
photoperiodism
response to zinc ion
melatonin biosynthetic process
response to insulin
response to cytokine
response to prostaglandin E
indolalkylamine biosynthetic process
response to copper ion
response to corticosterone
response to calcium ion
cellular response to cAMP
response to organic cyclic compound
rhythmic process
response to light stimulus
entrainment of circadian clock by photoperiod
response to cAMP
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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