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Product Details
10282-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AATF Fusion Protein Ag0195 (7-212 aa encoded by BC000591)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LALQLEQLL NPRPSEADPE ADPEEATAAR VIDRFDEGED GEGDFLVVGS IRKLASASLL DTDKRYCGKT TSRKAWNEDH WEQTLPGSSD EEISDEEGSG DEDSEGLGLE EYDEDDLGAA EEQECGDHRE SKKSRSHSAK TPGFSVQSIS DFEKFTKGMD DLGSSEEEED EESGMEEGDD AEDSQGESEE DRAGDRNSED DGVVMTF (7-212 aa encoded by BC000591)
Target Information
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-antagonizing transcription factor; Protein AATF; Rb-binding protein Che-1; Traube protein
Gene Aliases: 4933415H02Rik; 5830465M17Rik; AATF; BFR2; CHE-1; CHE1; DED; HSPC277; Trb
UniProt ID: (Human) B3KQ26, (Mouse) Q9JKX4, (Rat) Q9QYW0
Entrez Gene ID: (Human) 26574, (Mouse) 56321, (Rat) 114512
cellular response to DNA damage stimulus
cell adhesion
regulation of mitotic cell cycle
negative regulation of superoxide anion generation
embryonic cleavage
ribosome biogenesis
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of reactive oxygen species metabolic process
positive regulation of transcription, DNA-templated
apoptotic process
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