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Product Details
17693-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ABL2 Fusion Protein Ag11860 (822-1167 aa encoded by BC065912)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This protein has 9 isoforms produced by alternative splicing with the molecular weight from 114 kDa to 128 kDa. The antibody is specific to the others except the 60 kDa isoform of ABL2.
Immunogen sequence: SEESAAPSR ERPKAKLLPR GATALPLRTP SGDLAITEKD PPGVGVAGVA AAPKGKEKNG GARLGMAGVP EDGEQPGWPS PAKAAPVLPT THNHKVPVLI SPTLKHTPAD VQLIGTDSQG NKFKLLSEHQ VTSSGDKDRP RRVKPKCAPP PPPVMRLLQH PSICSDPTEE PTALTAGQST SETQEGGKKA ALGAVPISGK AGRPVMPPPQ VPLPTSSISP AKMANGTAGT KVALRKTKQA AEKISADKIS KEALLECADL LSSALTEPVP NSQLVDTGHQ LLDYCSGYVD CIPQTRNKFA FREAVSKLEL SLQELQVSSA AAGVPGTNPV LNNLLSCVQE ISDVVQR (822-1167 aa encoded by BC065912)
Target Information
ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl1-related gene product; abl2; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; tyrosine kinase ARG; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Gene Aliases: AA536808; ABL2; ABLL; ARG
UniProt ID: (Human) P42684
Entrez Gene ID: (Human) 27, (Mouse) 11352, (Rat) 304883
magnesium ion binding
actin monomer binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
manganese ion binding
actin filament binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
molecular_function
cellular protein modification process
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
positive regulation of phospholipase C activity
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton organization
regulation of endocytosis
regulation of cell adhesion
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
positive regulation of oxidoreductase activity
cellular response to retinoic acid
regulation of cell motility
regulation of actin cytoskeleton reorganization
protein phosphorylation
phagocytosis
substrate-dependent cell migration, cell extension
actin filament organization
epidermal growth factor receptor signaling pathway
learning
visual learning
phosphorylation
neuron remodeling
cerebellum morphogenesis
negative regulation of cell-cell adhesion
positive regulation of protein binding
cellular protein localization
negative regulation of Rho protein signal transduction
exploration behavior
positive regulation of I-kappaB kinase/NF-kappaB signaling
alpha-beta T cell differentiation
platelet-derived growth factor receptor signaling pathway
dendrite morphogenesis
neuromuscular process controlling balance
actin filament bundle assembly
Bergmann glial cell differentiation
positive regulation of ERK1 and ERK2 cascade
dendritic spine maintenance
positive regulation of interleukin-2 secretion
positive regulation of interferon-gamma secretion
regulation of extracellular matrix organization
positive regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of endothelial cell apoptotic process
biological_process
cell differentiation
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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