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AIP1 Antibody (OSA00243W-100UL) in IHC (P)
IHC-P on paraffin sections of rat spinal cord tissue. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers i... View More
Product Details
OSA00243W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 1050-1100 of human AIP1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: AIP1.
Target Information
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin receptor interacting protein 1; Activin receptor-interacting protein 1; Acvrip1; AIP-1; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Synaptic-scaffolding molecule
Gene Aliases: Acvri1; ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; KIAA0705; MAGI-2; MAGI2; mKIAA0705; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Rat) O88382, (Mouse) Q9WVQ1
Entrez Gene ID: (Human) 9863, (Rat) 113970, (Mouse) 50791
positive regulation of receptor internalization
glomerular filtration
signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
phosphorylation
cytosolic transport
negative regulation of cell migration
positive regulation of phosphoprotein phosphatase activity
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
protein heterooligomerization
negative regulation of protein kinase B signaling
SMAD protein signal transduction
mitotic cell cycle arrest
glomerular visceral epithelial cell development
cellular response to nerve growth factor stimulus
planar cell polarity pathway involved in axis elongation
neuroligin clustering involved in postsynaptic membrane assembly
positive regulation of synaptic vesicle clustering
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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