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Product Details
15108-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AIPL1 Fusion Protein Ag4625 (30-384 aa encoded by BC012055)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GSRVIFHFR TMKCDEERTV IDDSRQVGQP MHIIIGNMFK LEVWEILLTS MRVHEVAEFW CDTIHTGVYP ILSRSLRQMA QGKDPTEWHV HTCGLANMFA YHTLGYEDLD ELQKEPQPLV FVIELLQVDA PSDYQRETWN LSNHEKMKAV PVLHGEGNRL FKLGRYEEAS SKYQEAIICL RNLQTKEKPW EVQWLKLEKM INTLILNYCQ CLLKKEEYYE VLEHTSDILR HHPGIVKAYY VRARAHAEVW NEAEAKADLQ KVLELEPSMQ KAVRRELRLL ENRMAEKQEE ERLRCRNMLS QGATQPPAEP PTEPPAQSST EPPAEPPTAP SAELSAGPPA EPATEPPPSP GHSLQH (30-384 aa encoded by BC012055)
Target Information
Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aryl hydrocarbon receptor interacting protein-like 1; Aryl-hydrocarbon-interacting protein-like 1
Gene Aliases: A930007I01Rik; AIPL1; AIPL2; LCA4
UniProt ID: (Human) Q9NZN9, (Mouse) Q924K1, (Rat) Q9JLG9
Entrez Gene ID: (Human) 23746, (Mouse) 114230, (Rat) 59110
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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