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Product Details
PA5-66217
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human ASIC1. Recombinant protein control fragment (Product #RP-106899).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663081
Product Specific Information
Immunogen sequence: LALLNNRYEIP DTQMADEKQL EILQDKANFR SFKPKPFNMR EFYDRAGHDI RDMLLSCHFR GEVCSAEDFK VVFT
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACCN2 variant 3; acid sensing (proton gated) ion channel 1; acid sensing ion channel 1; acid-sensing (proton-gated) ion channel 1; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; Amiloride-sensitive cation channel 2, neuronal; ASIC1; BNaC2; Brain sodium channel 2; Cation channel, amiloride-sensitive, neuronal, 2; hBNaC2
Gene Aliases: ACCN2; ASIC; ASIC1; BNAC2
UniProt ID: (Human) P78348
Entrez Gene ID: (Human) 41
transport
sodium ion transport
signal transduction
memory
associative learning
response to pH
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
negative regulation of neurotransmitter secretion
sensory perception of sour taste
protein homotrimerization
calcium ion transmembrane transport
cellular response to pH
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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