Proteintech

ATP1A1 Polyclonal Antibody

ATP1A1 Antibody in Immunocytochemistry (ICC/IF)

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ATP1A1 Antibody (55187-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed Caco-2 cells using (Product # 55187-1-AP) (ATP1A1-Specific antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ATP1A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ATP1A1 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

55187-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.61 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to ATP1A1.

Target Information

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.

Cell metabolism

Zheng ZG,Xu YY,Liu WP,Zhang Y,Zhang C,Liu HL,Zhang XY,Liu RZ,Zhang YP,Shi MY,Yang H,Li P

Tue Jan 03 00:00:00 EST 2023

Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury.

Autophagy

Li Y,Xu J,Chen W,Wang X,Zhao Z,Li Y,Zhang L,Jiao J,Yang Q,Ding Q,Yang P,Wei L,Chen Y,Chen Y,Ruan XZ,Zhao L

Fri Sep 01 00:00:00 EDT 2023

Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.

Molecular brain

Cheng Q,Wu J,Xia Y,Cheng Q,Zhao Y,Zhu P,Zhang W,Zhang S,Zhang L,Yuan Y,Li C,Chen G,Xue B

Mon Feb 13 00:00:00 EST 2023

CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.

Experimental eye research

Wang Y,Jin C,Tian H,Xu J,Chen J,Hu S,Li Q,Lu L,Ou Q,Xu GT,Cui H

Wed Jun 01 00:00:00 EDT 2022

HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA_AR-mediated inhibitory synaptic transmission in pentylenetetrazole rat model.

Neuroscience research

Wen Y,Zhang G,Liu L,Zhang P,Lin L,Mei R,Zhang F,Chen Y,Li R

Thu Sep 01 00:00:00 EDT 2022

Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lin J,Jiang X,Dong M,Liu X,Shen Q,Huang Y,Zhang H,Ye R,Zhou H,Yan C,Yuan S,Wu X,Chen L,Wang Y,He M,Tao Y,Zhang Z,Jin W

Mon Nov 01 00:00:00 EDT 2021

Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.

Hypertension (Dallas, Tex. : 1979)

Shao S,Li XD,Lu YY,Li SJ,Chen XH,Zhou HD,He S,Guo YT,Lu X,Gao PJ,Wang JG

Wed Mar 03 00:00:00 EST 2021

The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training.

Metabolic brain disease

Liu B,Li J,Lin X,Hu J,Lou S

Sat Aug 01 00:00:00 EDT 2020

Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.

PloS one

Plössl K,Straub K,Schmid V,Strunz F,Wild J,Merkl R,Weber BHF,Friedrich U

Tue Jan 14 00:00:00 EST 2020

Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.

Molecular biology of the cell

Plössl K,Royer M,Bernklau S,Tavraz NN,Friedrich T,Wild J,Weber BHF,Friedrich U

Tue Aug 01 00:00:00 EDT 2017

Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.

Molecular biology of the cell

Plössl K,Royer M,Bernklau S,Tavraz NN,Friedrich T,Wild J,Weber BHF,Friedrich U

Tue Aug 01 00:00:00 EDT 2017

A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice.

PloS one

Liu M,Feng LX,Sun P,Liu W,Wu WY,Jiang BH,Yang M,Hu LH,Guo DA,Liu X

Fri Jul 28 00:00:00 EDT 2017

A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice.

PloS one

Liu M,Feng LX,Sun P,Liu W,Wu WY,Jiang BH,Yang M,Hu LH,Guo DA,Liu X

Fri Jul 28 00:00:00 EDT 2017

Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification.

Scientific reports

Xu Y,Xie J,Chen R,Cao Y,Ping Y,Xu Q,Hu W,Wu D,Gu L,Zhou H,Chen X,Zhao Z,Zhong J,Li R

Fri Nov 18 00:00:00 EST 2016

Bioinformatics

Protein Aliases: ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; RP4-655J12.1; Sodium Potassium ATPase; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; Sodium/potassium-transporting ATPase subunit alpha-1

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Gene Aliases: ATP1A1; Atpa-1; BC010319

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UniProt ID: (Human) P05023, (Mouse) Q8VDN2

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Entrez Gene ID: (Human) 476, (Mouse) 11928

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Function(s)

sodium:potassium-exchanging ATPase activity protein binding ATP binding phosphatase activity protein kinase binding protein domain specific binding ankyrin binding potassium ion binding sodium ion binding ADP binding phosphatidylinositol 3-kinase binding chaperone binding steroid hormone binding nucleotide binding hydrolase activity metal ion binding primary active transporter

Process(es)

regulation of the force of heart contraction regulation of sodium ion transport cellular sodium ion homeostasis regulation of blood pressure potassium ion import establishment or maintenance of transmembrane electrochemical gradient ATP hydrolysis coupled proton transport dephosphorylation cellular potassium ion homeostasis negative regulation of glucocorticoid biosynthetic process ion transmembrane transport sodium ion export from cell response to drug negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction relaxation of cardiac muscle cardiac muscle contraction membrane hyperpolarization cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane transport ion transport potassium ion transport sodium ion transport sodium ion transmembrane transport potassium ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATP1A1 Polyclonal Antibody

ATP1A1 Antibody (55187-1-AP) in ICC/IF

Product Details

55187-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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