Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
ATP1A1 Monoclonal Antibody (464.6)
Product Details
MA1-16731
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Fruit fly,
Guinea pig,
Human,
Mouse,
Non-human primate,
Sheep,
Pig,
Rabbit,
Rat,
Xenopus,
Yeast
Published species
Amphibian,
Guinea pig,
Human,
Rat,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
464.6
Immunogen
Purified Na,K-ATPase from rabbit renal outer medulla.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2060993
Product Specific Information
Do not boil samples prior to Western Blot.
Target Information
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (Na+, K+)-ATPase alpha-subunit; ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+ ,K+ -ATPase alpha subunit; Na+ /K+ ATPase alpha 1 subunit; Na+, K+-ATPase beta-subunit precursor; Na+/K+ -ATPase alpha 1 subunit; Na+/K+ ATPase; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na+/K+ transporting alpha 1 polypeptide; Na+K+ ATPase; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na/K ATPase alpha 1 subunit; RP4-655J12.1; Sodium Potassium ATPase; sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; sodium/potassium-ATPase alpha-subunit 1; sodium/potassium-transporting ATPase alpha-1 chain; Sodium/potassium-transporting ATPase subunit alpha-1; unnamed protein product
Gene Aliases: ATP1A1; atp1a1-a; atp1a1-b; atp1a1a.4; Atpa-1; BC010319; K-ATPase; Na+K+ATPase; Nkaa1b
UniProt ID: (Sheep) P04074, (Rabbit) Q9N0Z6, (Human) P05023, (Pig) P05024, (Bovine) Q08DA1, (Rat) P06685, (Mouse) Q8VDN2
sodium:potassium-exchanging ATPase activity
ATP binding
metal ion binding
protein binding
phosphatase activity
protein kinase binding
protein domain specific binding
ankyrin binding
potassium ion binding
sodium ion binding
ADP binding
phosphatidylinositol 3-kinase binding
chaperone binding
steroid hormone binding
ATPase binding
nucleotide binding
hydrolase activity
primary active transporter
regulation of sodium ion transport
sodium ion transport
establishment or maintenance of transmembrane electrochemical gradient
potassium ion transmembrane transport
regulation of the force of heart contraction
cellular sodium ion homeostasis
regulation of blood pressure
potassium ion import
ATP hydrolysis coupled proton transport
dephosphorylation
cellular potassium ion homeostasis
negative regulation of glucocorticoid biosynthetic process
ion transmembrane transport
sodium ion export from cell
response to drug
negative regulation of heart contraction
positive regulation of heart contraction
positive regulation of striated muscle contraction
relaxation of cardiac muscle
cardiac muscle contraction
membrane hyperpolarization
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
regulation of cardiac muscle cell contraction
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
response to glycoside
regulation of cardiac conduction
potassium ion import across plasma membrane
transmembrane transport
potassium ion transport
energy coupled proton transmembrane transport, against electrochemical gradient
sodium ion transmembrane transport
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support