Invitrogen

ATP1A1 Monoclonal Antibody (M8-P1-A3)

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

8 Published Figures

47 References

View all (40) ATP1A1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

ATP1A1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

ATP1A1 Antibody (MA3-929) in ICC/IF

Immunofluorescent analysis of sodiµm/potassium ATPase alpha-1 (green) in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 15 minutes at room temperature and blocked with 0.3% BSA for 15 minutes at room temperature. Cells were probed with a sodiµm/potassium ATPase alpha-1 monoclonal antibody (Product # MA3-929) at a dilution of 1:100 for at least 1 hour at room temperature, washed with PBS, and incubated with a DyLight 488-conjugated goat anti-mouse IgG secondary antibody (Product # 35502) at a dilution ... View More

ATP1A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

MA3-929

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:2,000

View 35 publications 35 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:2,000

Immunohistochemistry (Frozen) (IHC (F))

1:100

Immunocytochemistry (ICC/IF)

1/50 - 1/200

View 7 publications 7 publications

Flow Cytometry (Flow)

1/20 - 1/100

Neutralization (Neu)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Dog, Human, Mouse, Sheep, Pig, Rat

Published species

Bovine, Dog, Human, Invertebrate, Mouse, Non-human primate, Pig, Rat, Sheep, Yeast

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

M8-P1-A3

Immunogen

Lamb kidney alpha 1 sodium/potassium ATPase.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2061127

Product Specific Information

MA3-929 detects sodium/potassium ATPase alpha 1 in sheep, canine, rat, mouse, human and porcine tissues. This antibody does not detect the alpha 1 isoform in Xenopus and chicken. MA3-929 does not detect the alpha 2 or alpha 3 isoform in rat.

MA3-929 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, flow cytometry, and immunohistochemistry procedures. By Western blot, this antibody detects an ~110 kDa protein representing alpha 1 sodium/potassium ATPase from canine kidney extract. Immunohistochemical staining of sodium/potassium ATPase alpha 1 with MA3-929 yields a pattern consistent with plasma membrane localization.

The MA3-929 antigen is sheep kidney alpha 1 sodium/potassium ATPase. This antibody recognizes an epitope between amino acid residues 496-506 of lamb kidney sodium/potassium ATPase.

Target Information

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Non-Gastric H⁺/K⁺ ATPase (ATP12A) Is Expressed in Mammalian Spermatozoa.

International journal of molecular sciences

Favia M,Gerbino A,Notario E,Tragni V,Sgobba MN,Dell'Aquila ME,Pierri CL,Guerra L,Ciani E

MA3-929 was used in Immunocytochemistry to study ATP12A protein expression and localization in frozen/thawed spermatozoa from cattle, sheep and buffaloes.

Wed Jan 19 00:00:00 EST 2022

The Non-Gastric H⁺/K⁺ ATPase (ATP12A) Is Expressed in Mammalian Spermatozoa.

International journal of molecular sciences

Favia M,Gerbino A,Notario E,Tragni V,Sgobba MN,Dell'Aquila ME,Pierri CL,Guerra L,Ciani E

MA3-929 was used in Immunocytochemistry to study ATP12A protein expression and localization in frozen/thawed spermatozoa from cattle, sheep and buffaloes.

Wed Jan 19 00:00:00 EST 2022

The Non-Gastric H⁺/K⁺ ATPase (ATP12A) Is Expressed in Mammalian Spermatozoa.

International journal of molecular sciences

Favia M,Gerbino A,Notario E,Tragni V,Sgobba MN,Dell'Aquila ME,Pierri CL,Guerra L,Ciani E

MA3-929 was used in Immunocytochemistry to study ATP12A protein expression and localization in frozen/thawed spermatozoa from cattle, sheep and buffaloes.

Wed Jan 19 00:00:00 EST 2022

Structural basis of autoinhibition of the human NHE3-CHP1 complex.

Science advances

Dong Y,Li H,Ilie A,Gao Y,Boucher A,Zhang XC,Orlowski J,Zhao Y

MA3-929 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to find that a cytosolic helix-loop-helix motif in NHE3 blocks the intracellular cavity formed between the core and dimerization domains, functioning as an autoinhibitory element and hindering substrate transport.

Fri May 27 00:00:00 EDT 2022

Retromer retrieves the Wilson disease protein ATP7B from endolysosomes in a copper-dependent manner.

Journal of cell science

Das S,Maji S,Bhattacharya I,Saha T,Naskar N,Gupta A

MA3-929 was used in Western Blot to demonstrate that retromer regulates endolysosome to TGN trafficking of copper transporter ATP7B and it is dependent upon intracellular copper.

Thu Dec 24 00:00:00 EST 2020

Sum of peak intensities outperforms peak area integration in iTRAQ protein expression measurement by LC-MS/MS using a TripleTOF 5600+ platform.

Bioscience reports

Burat B,Gonzalez J,Sauvage FL,Aouad H,Arnion H,Pinault E,Marquet P,Essig M

MA3-929 was used in Western Blotting to propose the Mascot-jTRAQx-CiR-C strategy as a simple yet powerful data processing adjunct to the iTRAQ technology.

Fri Jun 28 00:00:00 EDT 2019

A large-conductance calcium-regulated K+ channel in human dermal fibroblast mitochondria.

The Biochemical journal

Kicinska A,Augustynek B,Kulawiak B,Jarmuszkiewicz W,Szewczyk A,Bednarczyk P

MA3929 was used in western blot to discover a large-conductance calcium-regulated potassium channel in the inner mitochondrial membrane of human dermal fibroblasts

Thu Dec 01 00:00:00 EST 2016

Increased expression of mitochondrial DNA-encoded genes in human renal mesangial cells in response to high glucose-induced reactive oxygen species.

Molecular medicine reports

Al-Kafaji G,Sabry MA,Bakhiet M

MA3-929 was used in Western Blotting to examine changes in expression of mitochondrial DNA-encoded genes in response to high glucose-induced reactive oxygen species overproduction.

Mon Feb 01 00:00:00 EST 2016

Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Ponce A,Larre I,Castillo A,Flores-Maldonado C,Verdejo-Torres O,Contreras RG,Cereijido M

MA3929 was used in immunohistochemistry to test if ouabain alters Cnx43 expression and distribution

Tue Jan 31 00:00:00 EST 2017

The Apical Localization of Na⁺, K⁺-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β₂ Subunit.

Frontiers in physiology

Lobato-Álvarez JA,Roldán ML,López-Murillo TD,González-Ramírez R,Bonilla-Delgado J,Shoshani L

MA3929 was used in immunocytochemistry to show that apical polarization of the sodium, potassium-ATPase in retinal pigment epithelium cells depends on the expression of the beta2 subunit

Wed Sep 30 00:00:00 EDT 2020

FXYD2, a γ subunit of Na⁺, K⁺-ATPase, maintains persistent mechanical allodynia induced by inflammation.

Cell research

Wang F,Cai B,Li KC,Hu XY,Lu YJ,Wang Q,Bao L,Zhang X

MA3-929 was used in immunoprecipitation and western blot to determine a role for FXYD2 in neurons using knock out mice

Sun Mar 01 00:00:00 EST 2015

EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.

Journal of cellular physiology

García-Hernández V,Flores-Maldonado C,Rincon-Heredia R,Verdejo-Torres O,Bonilla-Delgado J,Meneses-Morales I,Gariglio P,Contreras RG

MA3-929 was used in immunocytochemistry to investigate the effect of EGF on claudin-2 and -4 expression in MDCK cells

Thu Jan 01 00:00:00 EST 2015

Regulation and pharmacological blockade of sodium-potassium ATPase: a novel pathway to neuropathy.

Journal of the neurological sciences

Paul D,Soignier RD,Minor L,Tau H,Songu-Mize E,Gould HJ

MA3-929 was used in Western Blotting to find evidence that regulation of Na(+), K(+)-ATPase during major inflammatory disease states is critical for homeostatic protection of primary afferent neurons.

Thu May 15 00:00:00 EDT 2014

Large-conductance Ca²⁺-activated potassium channel in mitochondria of endothelial EA.hy926 cells.

American journal of physiology. Heart and circulatory physiology

Bednarczyk P,Koziel A,Jarmuszkiewicz W,Szewczyk A

MA3-929 was used in western blot to study the presence and functional characteristics of a large-conductance Ca(2+)-activated K(+) channel in EA.hy926 endothelial cell inner mitochondrial membranes

Sat Jun 01 00:00:00 EDT 2013

Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.

Experimental cell research

Pinder JC,Taylor-Harris PM,Bennett PM,Carter E,Hayes NV,King MD,Holt MR,Maggs AM,Gascard P,Baines AJ

MA3-929 was used in western blot to study the expression and localization of protein4.1 isoforms in cardiac muscle and the significance for cardiomyocyte Ca(2+) metabolism

Wed Aug 01 00:00:00 EDT 2012

Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS).

Proceedings of the National Academy of Sciences of the United States of America

Paroder-Belenitsky M,Maestas MJ,Dohán O,Nicola JP,Reyna-Neyra A,Follenzi A,Dadachova E,Eskandari S,Amzel LM,Carrasco N

MA3-929 was used in western blot to study the structural and mechanistic features of sodium iodine symporter

Tue Nov 01 00:00:00 EDT 2011

Ouabain modulates ciliogenesis in epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America

Larre I,Castillo A,Flores-Maldonado C,Contreras RG,Galvan I,Muñoz-Estrada J,Cereijido M

MA3-929 was used in immunocytochemistry to investigate the effect of ouabain on cilia development in epithelial cells

Tue Dec 20 00:00:00 EST 2011

Influence of renal compensatory hypertrophy on mitochondrial energetics and redox status.

Biochemical pharmacology

Benipal B,Lash LH

MA3-929 was used in western blot to investigate the molecular mechanism of renal compensatory hypertrophy in a uninephrectomized rat model

Sat Jan 15 00:00:00 EST 2011

Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.

Molecular and cellular neurosciences

Rao A,Simmons D,Sorkin A

MA3-929 was used in immunocytochemistry to study the subcellular distribution and functions of endosomal compartments and dopamine transporter in dopaminergic neurons

Sat Jan 01 00:00:00 EST 2011

A role for mineralocorticoid receptors in the physiology of the ovine fetus: effects on ACTH and lung liquid composition.

Pediatric research

Keller-Wood M,Wood CE,McCartney J,Jesse NM,Perrone D

MA3-929 was used in western blot to investigate the effect of mineralocorticoid receptors on plasma ACTH and lung fluid composition during lung development

Wed Jun 01 00:00:00 EDT 2011

A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.

Pacing and clinical electrophysiology : PACE

Chen J,Weber M,Um SY,Walsh CA,Tang Y,McDonald TV

MA3-929 was used in western blot to investigate the role of a deleterious mutation of KCNQ1-S277L in hereditary long QT syndrome

Thu Dec 01 00:00:00 EST 2011

Rotavirus NSP4: Cell type-dependent transport kinetics to the exofacial plasma membrane and release from intact infected cells.

Virology journal

Gibbons TF,Storey SM,Williams CV,McIntosh A,Mitchel DM,Parr RD,Schroeder ME,Schroeder F,Ball JM

MA3-929 was used in immunocytochemistry to study the intracellular transport of rotavirus NSP4 and its release from intact cells

Mon Jun 06 00:00:00 EDT 2011

Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity.

The Journal of biological chemistry

Lyons PJ,Fricker LD

MA3-929 was used in immunocytochemistry to investigate the structural and functional properties of carboxypeptidase O

Fri Nov 11 00:00:00 EST 2011

Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight.

Cell metabolism

Alekseev AE,Reyes S,Yamada S,Hodgson-Zingman DM,Sattiraju S,Zhu Z,Sierra A,Gerbin M,Coetzee WA,Goldhamer DJ,Terzic A,Zingman LV

MA3-929 was used in western blot to investigate the role of Sarcolemmal ATP-sensitive K(+) channels in body weight determination and obesity

Fri Jan 01 00:00:00 EST 2010

The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.

Experimental neurology

Hyun DH,Mughal MR,Yang H,Lee JH,Ko EJ,Hunt ND,de Cabo R,Mattson MP

MA3-929 was used in western blot to investigate the effect of amyloid beta-peptide on plasma membrane redox system

Fri Oct 01 00:00:00 EDT 2010

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.

The Journal of biological chemistry

Perrotta C,Bizzozero L,Cazzato D,Morlacchi S,Assi E,Simbari F,Zhang Y,Gulbins E,Bassi MT,Rosa P,Clementi E

MA3-929 was used in western blot to study the activation of acid sphingomyelinase activity by syntaxin 4.

Fri Dec 17 00:00:00 EST 2010

Is the fetal lung a mineralocorticoid receptor target organ? Induction of cortisol-regulated genes in the ovine fetal lung, kidney and small intestine.

Neonatology

Keller-Wood M,von Reitzenstein M,McCartney J

MA3-929 was used in western blot to study the function of mineralocorticoid receptor in fetal lungs

Thu Jun 04 00:00:00 EDT 2009

Regulation of Na,K-ATPase subunit abundance by translational repression.

The Journal of biological chemistry

Clifford RJ,Kaplan JH

MA3-929 was used in western blot to study how translational repression regulates alpha and beta subunit of Na, K-ATPase's expression

Fri Aug 21 00:00:00 EDT 2009

beta-Subunit overexpression alters the stoicheometry of assembled Na-K-ATPase subunits in MDCK cells.

American journal of physiology. Renal physiology

Clifford RJ,Kaplan JH

Published figure using ATP1A1 monoclonal antibody (Product # MA3-929) in Western Blot

Sat Nov 01 00:00:00 EDT 2008

Selective basolateral localization of overexpressed Na-K-ATPase beta1- and beta2- subunits is disrupted by butryate treatment of MDCK cells.

American journal of physiology. Renal physiology

Laughery MD,Clifford RJ,Chi Y,Kaplan JH

MA3-929 was used in western blot to investigate the distribution of the sodium/potassium-ATPase beta 1- and beta 2-subunit isoforms stably expressed in MDCK cells and regulation by tetracycline

Fri Jun 01 00:00:00 EDT 2007

Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue.

Circulation research

Lunde PK,Sejersted OM,Thorud HM,Tønnessen T,Henriksen UL,Christensen G,Westerblad H,Bruton J

MA3-929 was used in Western Blotting to examine the mechanisms causing soleus fibres in rats with congestive heart failure to fatigue more rapidly than in healthy rats.

Fri Jun 23 00:00:00 EDT 2006

A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity.

Biophysical journal

Xiong L,Zhang JZ,He R,Hamilton SL

MA3-929 was used in western blot to study the interaction of a fragment of RyR1 (R4064-C4210) with Cav1.1

Sun Jan 01 00:00:00 EST 2006

Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system.

Biochimica et biophysica acta

Fernández-Ayala DJ,Brea-Calvo G,López-Lluch G,Navas P

MA3-929 was used in western blot to study the role of endomembrane system in coenzyme Q distribution in HL-60 human cells

Sat Jul 30 00:00:00 EDT 2005

Mineralocorticoid receptor expression in late-gestation ovine fetal lung.

Journal of the Society for Gynecologic Investigation

Keller-Wood M,Wood CE,Hua Y,Zhang D

MA3-929 was used in immunohistochemistry to investigate the distribution of mineralocorticoid receptor in the lung of late-gestation sheep fetus

Tue Feb 01 00:00:00 EST 2005

Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.

Journal of lipid research

Keller RK,Arnold TP,Fliesler SJ

MA3-929 was used in western blot to investigate the ability of 7-dehydrocholesterol to replace cholesterol in membrane rafts.

Sun Feb 01 00:00:00 EST 2004

Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.

Journal of lipid research

Keller RK,Arnold TP,Fliesler SJ

MA3-929 was used in western blot to investigate the ability of 7-dehydrocholesterol to replace cholesterol in membrane rafts.

Sun Feb 01 00:00:00 EST 2004

Vitamin D3 upregulates plasma membrane Ca2+-ATPase expression and potentiates apico-basal Ca2+ flux in MDCK cells.

American journal of physiology. Renal physiology

Kip SN,Strehler EE

MA3-929 was used in western blot to determine the regulatory role of VitD in active calcium reuptake in the distal kidney.

Sun Feb 01 00:00:00 EST 2004

Detergent-resistant membrane microdomains facilitate Ib oligomer formation and biological activity of Clostridium perfringens iota-toxin.

Infection and immunity

Hale ML,Marvaud JC,Popoff MR,Stiles BG

MA3-929 was used in western blot to locate iota b (Ib) oligomers in detergent-resistant membrane microdomains (DRMs) extracted from Vero cells

Thu Apr 01 00:00:00 EST 2004

Polyuria and impaired renal blood flow after asphyxia in preterm fetal sheep.

American journal of physiology. Regulatory, integrative and comparative physiology

Quaedackers JS,Roelfsema V,Hunter CJ,Heineman E,Gunn AJ,Bennet L

MA3-929 was used in immunohistochemistry to assess the presence of renal damage in preterm fetal sheep after asphyxia

Mon Mar 01 00:00:00 EST 2004

Oligomerization of the Na,K-ATPase in cell membranes.

The Journal of biological chemistry

Laughery M,Todd M,Kaplan JH

Published figure using ATP1A1 monoclonal antibody (Product # MA3-929) in Western Blot

Fri Aug 27 00:00:00 EDT 2004

Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors.

The Journal of physiology

Johansson C,Lunde PK,Gothe S,Lannergren J,Westerblad H

MA3-929 was used in western blot to investigate the isometric force and endurance in the muscles of mice deficient in TRalpha1 or TRbeta.

Sat Mar 15 00:00:00 EST 2003

Mutational analysis of alpha-beta subunit interactions in the delivery of Na,K-ATPase heterodimers to the plasma membrane.

The Journal of biological chemistry

Laughery MD,Todd ML,Kaplan JH

MA3-929 was used in western blot to study the transport of sodium/potassium ATPase heterodimers to plasma membrane.

Fri Sep 12 00:00:00 EDT 2003

Mutational analysis of alpha-beta subunit interactions in the delivery of Na,K-ATPase heterodimers to the plasma membrane.

The Journal of biological chemistry

Laughery MD,Todd ML,Kaplan JH

MA3-929 was used in western blot to study the transport of sodium/potassium ATPase heterodimers to plasma membrane.

Fri Sep 12 00:00:00 EDT 2003

Action of palytoxin on apical H+/K+-ATPase in rat colon.

European journal of biochemistry

Scheiner-Bobis G,Hübschle T,Diener M

MA3-929 was used in immunohistochemistry to study how palytoxin affects the hydrogen/potassium-ATPase from the rat colon

Thu Aug 01 00:00:00 EDT 2002

Functional properties of the copper-transporting ATPase ATP7B (the Wilson's disease protein) expressed in insect cells.

The Journal of biological chemistry

Tsivkovskii R,Eisses JF,Kaplan JH,Lutsenko S

MA3-929 was used in western blot to detect the expression of Na,K-ATPase

Fri Jan 11 00:00:00 EST 2002

Contraction and intracellular Ca(2+) handling in isolated skeletal muscle of rats with congestive heart failure.

Circulation research

Lunde PK,Dahlstedt AJ,Bruton JD,Lännergren J,Thorén P,Sejersted OM,Westerblad H

MA3-929 was used in western blot to study the contraction and intracellular calcium handling in rat skeletal muscle

Fri Jun 22 00:00:00 EDT 2001

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain.

Human molecular genetics

Takeda K,Inoue H,Tanizawa Y,Matsuzaki Y,Oba J,Watanabe Y,Shinoda K,Oka Y

MA3-929 was used in western blot to investigate the role of the WFS1 protein in maintaining certain populations of neuronal and endocrine cells.

Thu Mar 01 00:00:00 EST 2001

Are B-type Ca2+ channels of cardiac myocytes akin to the passive ion channel in the plasma membrane Ca2+ pump?

The Journal of membrane biology

Antoine S,Pinet C,Coulombe A

MA3-929 was used in blocking or activating experiment to study the relationship of the cardiac B-type Ca(2+) channel to the plasma membrane Ca(2+)-ATPase pump

Mon Jan 01 00:00:00 EST 2001

Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha(1)- or -beta-deficient mice.

American journal of physiology. Regulatory, integrative and comparative physiology

Johansson C,Lännergren J,Lunde PK,Vennström B,Thorén P,Westerblad H

MA3-929 was used in western blot to investigate the role of thyroid hormone receptor (TR)-alpha1 and -beta on skeletal muscle function

Wed Mar 01 00:00:00 EST 2000

Substitution of glutamic 779 with alanine in the Na,K-ATPase alpha subunit removes voltage dependence of ion transport.

The Journal of biological chemistry

Argüello JM,Peluffo RD,Feng J,Lingrel JB,Berlin JR

MA3-929 was used in western blot to investigate the importance of Glu 779 in functional properties of sodium/potassium-ATPase alpha 1

Fri Oct 04 00:00:00 EDT 1996

Interactions of phosphorylation and dimerizing domains of the alpha-subunits of Na+/K(+)-ATPase.

The Journal of biological chemistry

Ganjeizadeh M,Zolotarjova N,Huang WH,Askari A

MA3-929 was used in western blot to identify the dimerization domain of sodium/potassium-ATPase, which is regulated by the corresponding phosphorylation status

Fri Jun 30 00:00:00 EDT 1995

Bioinformatics

Protein Aliases: (Na+, K+)-ATPase alpha-subunit; ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+ ,K+ -ATPase alpha subunit; Na+ /K+ ATPase alpha 1 subunit; Na+, K+-ATPase beta-subunit precursor; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na+/K+ transporting alpha 1 polypeptide; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; RP4-655J12.1; Sodium Potassium ATPase; sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; sodium/potassium-transporting ATPase alpha-1 chain; Sodium/potassium-transporting ATPase subunit alpha-1; unnamed protein product

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Gene Aliases: ATP1A1; Atpa-1; BC010319; Nkaa1b

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UniProt ID: (Sheep) P04074, (Human) P05023, (Pig) P05024, (Rat) P06685, (Mouse) Q8VDN2

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Entrez Gene ID: (Dog) 403992, (Sheep) 443381, (Human) 476, (Pig) 397481, (Rat) 24211, (Mouse) 11928

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Function(s)

sodium:potassium-exchanging ATPase activity ATP binding metal ion binding protein binding phosphatase activity protein kinase binding protein domain specific binding ankyrin binding potassium ion binding sodium ion binding ADP binding phosphatidylinositol 3-kinase binding chaperone binding steroid hormone binding ATPase binding nucleotide binding hydrolase activity primary active transporter

Process(es)

regulation of sodium ion transport sodium ion transport establishment or maintenance of transmembrane electrochemical gradient potassium ion transmembrane transport regulation of the force of heart contraction cellular sodium ion homeostasis regulation of blood pressure potassium ion import ATP hydrolysis coupled proton transport dephosphorylation cellular potassium ion homeostasis negative regulation of glucocorticoid biosynthetic process ion transmembrane transport sodium ion export from cell response to drug negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction relaxation of cardiac muscle cardiac muscle contraction membrane hyperpolarization cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane transmembrane transport potassium ion transport energy coupled proton transmembrane transport, against electrochemical gradient sodium ion transmembrane transport transport ion transport

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ATP1A1 Monoclonal Antibody (M8-P1-A3)

ATP1A1 Antibody (MA3-929) in ICC/IF

Product Details

MA3-929

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Neutralization (Neu)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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