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Aminoacylase Antibody (MA5-25618) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human liver tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a ACY1 monoclonal antibody (Product # MA5-25618).
Product Details
MA5-25618
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2D3
Immunogen
Full length human recombinant protein of ACY1 produced in HEK293 cell
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2722864
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACY IA; ACY IB; ACY-1; ACY-1A; ACY-1B; acylase; Aminoacylase-1; Aminoacylase-1A; aminoacylase-1B; epididymis secretory protein Li 5; N-acyl-L-amino-acid amidohydrolase
Gene Aliases: 1110014J22Rik; ACY-1; ACY1; Acy1a; Acy1b; ACY1D; HEL-S-5
UniProt ID: (Human) Q03154, (Rat) Q6AYS7, (Mouse) Q99JW2
Entrez Gene ID: (Dog) 476602, (Human) 95, (Rat) 300981, (Mouse) 109652
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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