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ApoC3 Antibody (MA5-42767) in IHC (P)
Immunohistochemistry analysis of ApoC3 in paraffin-embedded human liver. Samples were incubated with ApoC3 Monoclonal antibody (Product # MA5-42767) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-42767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3T7Y5
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-99 of human Apolipoprotein C3 (P02656).
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911908
Product Specific Information
Positive test controls include: Human plasma.
Immunogen sequence: MQPRVLLVVA LLALLASARA SEAEDASLLS FMQGYMKHAT KTAKDALSSV QESQVAQQAR GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA
Target Information
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-CIII; apoC-III; Apolipoprotein; Apolipoprotein C-III; Apolipoprotein C3; MGC150353
Gene Aliases: apo-CIII; apoC-III; APOC3; APOCIII; HALP2
UniProt ID: (Human) P02656, (Mouse) P33622
Entrez Gene ID: (Human) 345, (Mouse) 11814
retinoid metabolic process
triglyceride metabolic process
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
triglyceride catabolic process
regulation of Cdc42 protein signal transduction
response to vitamin A
cholesterol efflux
phospholipid efflux
response to triglyceride
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
lipoprotein metabolic process
response to drug
cholesterol homeostasis
lipoprotein transport
response to peptide hormone
reverse cholesterol transport
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of lipoprotein lipase activity
negative regulation of cholesterol import
triglyceride homeostasis
response to fatty acid
cellular response to glucose stimulus
negative regulation of oxidative phosphorylation
response to simvastatin
lipid metabolic process
triglyceride mobilization
transport
lipid transport
cholesterol metabolic process
lipid catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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