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Product Details
MA5-41566
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Pig
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
D18
Immunogen
Recombinant protein Clusterin. The antigen corresponds to amino acid range 229-446 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899048
Target Information
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aging associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; CLI; Clusterin; Clusterin alpha / beta chain; Complement associated protein SP40; Complement cytolysis inhibitor; CP40; GP80; HGNC:2095; Ku70-binding protein 1 (KUB1); MGC24903; Sulfated glycoprotein 2 (SGP2); Testosterone repressed prostate message 2 (TPRM2B)
Gene Aliases: CLU
UniProt ID: (Pig) Q29549
Entrez Gene ID: (Pig) 397025
cell morphogenesis
microglial cell activation
immune complex clearance
response to virus
protein import
negative regulation of protein complex assembly
positive regulation of protein complex assembly
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of tumor necrosis factor production
regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of receptor-mediated endocytosis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
intrinsic apoptotic signaling pathway
regulation of beta-amyloid clearance
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
negative regulation of response to endoplasmic reticulum stress
negative regulation of cellular response to thapsigargin
negative regulation of cellular response to tunicamycin
negative regulation of amyloid fibril formation
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
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