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Product Details
X1653P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the autotaxin protein
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Human brain lysate (Cat. No. X1633C).
Target Information
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autotaxin; autotaxin-t; AutotaxinATX; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
Gene Aliases: ATX; ATX-X; AUTOTAXIN; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2
UniProt ID: (Human) Q13822
Entrez Gene ID: (Human) 5168
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
lysophospholipase activity
scavenger receptor activity
calcium ion binding
transcription factor binding
zinc ion binding
hydrolase activity
polysaccharide binding
alkylglycerophosphoethanolamine phosphodiesterase activity
phosphate-containing compound metabolic process
receptor-mediated endocytosis
movement of cell or subcellular component
chemotaxis
immune response
G-protein coupled receptor signaling pathway
phospholipid catabolic process
positive regulation of epithelial cell migration
regulation of cell migration
phosphatidylcholine catabolic process
regulation of angiogenesis
positive regulation of peptidyl-tyrosine phosphorylation
nucleic acid phosphodiester bond hydrolysis
positive regulation of lamellipodium morphogenesis
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