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BAIAP2 Antibody (BSM-51410M) in WB
Lane 1: K562 Cell lysates; Lane 2: mouse brain lysates; Lane 3: U-251 MG Cell lysates; probed with BAIAP2 (1037CT15.1.3) Monoclonal Antibody, unconjugated (bsm-51410M) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
Product Details
BSM-51410M
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4G7
Immunogen
Purified His-tagged BAIAP2 protein was used to produced this monoclonal antibody.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 40% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; insulin receptor substrate of 53 kDa; insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase 53 kDa substrate; IRS-58; IRSp53; IRSp53/58
Gene Aliases: BAIAP2; BAP2; FLAF3; IRSP53; R75030
UniProt ID: (Human) Q9UQB8, (Mouse) Q8BKX1
Entrez Gene ID: (Human) 10458, (Mouse) 108100
plasma membrane organization
axonogenesis
insulin receptor signaling pathway
regulation of cell shape
response to bacterium
dendrite development
positive regulation of actin filament polymerization
regulation of actin cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
vascular endothelial growth factor receptor signaling pathway
regulation of synaptic plasticity
actin filament bundle assembly
actin crosslink formation
positive regulation of dendritic spine morphogenesis
cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
Rho protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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