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BAIAP2L1 Antibody (PA5-121180) in WB
Western blot analysis of BAIAP2L1 in extracts of various cell lines. Samples were incubated with BAIAP2L1 Polyclonal antibody (Product # PA5-121180) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-121180
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 198-388 of human BAIAP2L1 (NP_061330.2).
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914752
Product Specific Information
Positive test controls include: HepG2, HeLa, 293T, A-549, Mouse lung. The target is usually found in the following locations: Cytoplasm, cytoskeleton.
Immunogen sequence: DKHCGFANHI HYYHLQSAEL LNSKLPRWQE TCVDAIKVPE KIMNMIEEIK TPASTPVSGT PQASPMIERS NVVRKDYDTL SKCSPKMPPA PSGRAYTSPL IDMFNNPATA APNSQRVNNS TGTSEDPSLQ RSVSVATGLN MMKKQKVKTI FPHTAGSNKT LLSFAQGDVI TLLIPEEKDG WLYGEHDVSK A
Target Information
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
Gene Aliases: 1300006M19Rik; AI585895; BAIAP2L1; IRTKS
UniProt ID: (Human) Q9UHR4, (Mouse) Q9DBJ3
Entrez Gene ID: (Human) 55971, (Mouse) 66898
plasma membrane organization
insulin receptor signaling pathway
response to bacterium
positive regulation of actin filament polymerization
regulation of insulin receptor signaling pathway
actin filament bundle assembly
actin crosslink formation
cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
regulation of actin filament polymerization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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