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Product Details
MA5-38094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC2085
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-89 of human BANF1 (O75531)
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898012
Product Specific Information
Positive Samples: HeLa, 293T, HepG2
Immunogen sequence: MTTSQKHRDF VAEPMGEKPV GSLAGIGEVL GKKLEERGFD KAYVVLGQFL VLKKDEDLFR EWLKDTCGAN AKQSRDCFGC LREWCDAFL
Target Information
Barrier-to-autointegration factor 1 (BANF1) is a conserved chromatin protein that non-specifically binds double-stranded DNA. BANF1 also interacts with a family of nuclear proteins that include LAP2, emerin, and MAN1. It is also a host cell component of retroviral pre-integration complexes (PICs), including that of HIV. BANF1 will bind to p55 Gag (the structural precursor of HIV-1 virions) as well as its cleaved product matrix. In addition to being a host cell component of the PIC, it is thought that BANF1 is also present at low levels in incoming virions, and thus might contribute to the assembly or activity of HIV-1 PICs through direct binding to matrix as well as DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Barrier-to-autointegration factor; Breakpoint cluster region protein 1; Breakpoint cluster region protein, uterine leiomyoma, 1; Breakpoint cluster region protein, uterine leiomyoma, 1; barrier to autointegration factor; Lap2 binding protein 1; LAP2-binding protein 1
Gene Aliases: BAF; BANF1; BCRG1; BCRP1; D14S1460; L2bp1; L2bp1/Baf; NGPS
UniProt ID: (Human) O75531, (Mouse) O54962, (Rat) Q9R1T1
Entrez Gene ID: (Human) 8815, (Mouse) 23825, (Rat) 114087
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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