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Product Details
14460-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BBS9 Fusion Protein Ag5665 (1-310 aa encoded by BC032715)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGYLRIFSP HPAKTGDGAQ AEDLLLEVDL RDPVLQVEVG KFVSGTEMLH LAVLHSRKLC VYSVSGTLGN VEHGNQCQMK LMYEHNLQRT ACNMTYGSFG GVKGRDLICI QSMDGMLMVF EQESYAFGRF LPGFLLPGPL AYSSRTDSFL TVSSCQQVES YKYQVLAFAT DADKRQETEQ QKLGSGKRLV VDWTLNIGEQ ALDICIVSFN QSASSVFVLG ERNFFCLKDN GQIRFMKKLD WSPSCFLPYC SVSEGTINTL IGNHNNMLHI YQDVTLKWAT QLPHIPVAVR VGCLQFSLWK HLLPRSSTLE K (1-310 aa encoded by BC032715)
Target Information
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 9 protein; Bardet-Biedl syndrome 9 protein homolog; EST 3159894; Parathyroid hormone-responsive B1 gene protein; Parathyroid hormone-responsive B1 gene protein homolog; Protein PTHB1; PTH-responsive osteosarcoma B1 protein
Gene Aliases: B1; BBS9; C18; D1; E130103I17Rik; PTHB1
UniProt ID: (Human) Q3SYG4, (Mouse) Q811G0
Entrez Gene ID: (Human) 27241, (Mouse) 319845
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