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Product Details
10775-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BLVRA Fusion Protein Ag1166 (1-296 aa encoded by BC008456)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNAEPERKF GVVVVGVGRA GSVRMRDLRN PHPSSAFLNL IGFVSRRELG SIDGVQQISL EDALSSQEVE VAYICSESSS HEDYIRQFLN AGKHVLVEYP MTLSLAAAQE LWELAEQKGK VLHEEHVELL MEEFAFLKKE VVGKDLLKGS LLFTAGPLEE ERFGFPAFSG ISRLTWLVSL FGELSLVSAT LEERKEDQYM KMTVCLETEK KSPLSWIEEK GPGLKRNRYL SFHFKSGSLE NVPNVGVNKN IFLKDQNIFV QKLLGQFSEK ELAAEKKRIL HCLGLAEEIQ KYCCSRK (1-296 aa encoded by BC008456)
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin-IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Biliverdin reductase A; Biliverdin-IX alpha-reductase; BVR A; EC 1.3.1.24; testis tissue sperm-binding protein Li 61n
Gene Aliases: 0610006A11Rik; 2500001N03Rik; BLVR; BLVRA; BVR; BVRA
UniProt ID: (Human) P53004, (Mouse) Q9CY64
Entrez Gene ID: (Human) 644, (Mouse) 109778
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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