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Product Details
PA5-142451
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-PETSNPNKPKRQTNQ.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933099
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_490597.1; NP_055114.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; the longer variant has a C-terminus region with a praline and glutamine-rich domains. BRD4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. BRD4 acts at different stages of the cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRD4-NUT FUSION; bromodomain-containing 5; Bromodomain-containing protein 4; fsh-like protein; MCAP; Mitotic chromosome-associated protein
Gene Aliases: Brd4; Brd5; HUNK1; MCAP; WI-11513
UniProt ID: (Mouse) Q9ESU6
Entrez Gene ID: (Mouse) 57261
regulation of transcription involved in G1/S transition of mitotic cell cycle
inner cell mass cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
chromosome segregation
positive regulation of G2/M transition of mitotic cell cycle
chromatin modification
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA binding
histone H4-K12 acetylation
histone H3-K14 acetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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