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Immunogen sequence: DCFEVTLKCE EGEDEEEAMV VAVIPRPEPM LRVTQQEKTP PPRPSPLEAG SDGCEEPKQQ VSWEQEFLVG SSPGGSGRAL CMVCGAEIRA PS
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.
Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hypothetical protein BC007540; SPIN-DOC; SPIN1-docking protein; Spindlin interactor and repressor of chromatin-binding protein
Gene Aliases: C11orf84; SPINDOC
UniProt ID: (Human) Q9BUA3
Entrez Gene ID: (Human) 144097
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