Proteintech

C1S Polyclonal Antibody

C1S Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

C1S Antibody (14554-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 14554-1-AP) (C1S antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

14554-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

C1S Fusion Protein Ag5977 (166-688 aa encoded by BC056903)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DDMKNCGVN CSGDVFTALI GEIASPNYPK PYPENSRCEY QIRLEKGFQV VVTLRREDFD VEAADSAGNC LDSLVFVAGD RQFGPYCGHG FPGPLNIETK SNALDIIFQT DLTGQKKGWK LRYHGDPMPC PKEDTPNSVW EPAKAKYVFR DVVQITCLDG FEVVEGRVGA TSFYSTCQSN GKWSNSKLKC QPVDCGIPES IENGKVEDPE STLFGSVIRY TCEEPYYYME NGGGGEYHCA GNGSWVNEVL GPELPKCVPV CGVPREPFEE KQRIIGGSDA DIKNFPWQVF FDNPWAGGAL INEYWVLTAA HVVEGNREPT MYVGSTSVQT SRLAKSKMLT PEHVFIHPGW KLLEVPEGRT NFDNDIALVR LKDPVKMGPT VSPICLPGTS SDYNLMDGDL GLISGWGRTE KRDRAVRLKA ARLPVAPLRK CKEVKVEKPT ADAEAYVFTP NMICAGGEKG MDSCKGDSGG AFAVQDPNDK TKFYAAGLVS WGPQCGTYGL YTRVKNYVDW IMKTMQENST PRED (166-688 aa encoded by B C056903)

Target Information

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Natural antibodies and CRP drive anaphylatoxin production by urate crystals.

Scientific reports

Wessig AK,Hoffmeister L,Klingberg A,Alberts A,Pich A,Brand K,Witte T,Neumann K

Wed Mar 16 00:00:00 EDT 2022

Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine Retina.

International journal of molecular sciences

Enzbrenner A,Zulliger R,Biber J,Pousa AMQ,Schäfer N,Stucki C,Giroud N,Berrera M,Kortvely E,Schmucki R,Badi L,Grosche A,Pauly D,Enzmann V

Thu Aug 26 00:00:00 EDT 2021

C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.

Scientific reports

Alberts A,Klingberg A,Wessig AK,Combes C,Witte T,Brand K,Pich A,Neumann K

Tue Apr 14 00:00:00 EDT 2020

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina.

Cell reports

Pauly D,Agarwal D,Dana N,Schäfer N,Biber J,Wunderlich KA,Jabri Y,Straub T,Zhang NR,Gautam AK,Weber BHF,Hauck SM,Kim M,Curcio CA,Stambolian D,Li M,Grosche A

Tue Nov 26 00:00:00 EST 2019

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina.

Cell reports

Pauly D,Agarwal D,Dana N,Schäfer N,Biber J,Wunderlich KA,Jabri Y,Straub T,Zhang NR,Gautam AK,Weber BHF,Hauck SM,Kim M,Curcio CA,Stambolian D,Li M,Grosche A

Tue Nov 26 00:00:00 EST 2019

Bioinformatics

Protein Aliases: basic proline-rich peptide IB-1; C1 esterase; Complement C1s subcomponent; Complement C1s-1 subcomponent; Complement C1s-A subcomponent; Complement component 1 subcomponent s; Complement component 1 subcomponent s-A; Complement component 1, S subcomponent 1; complement component C1SA; serine protease

View more View less

Gene Aliases: AA959438; AI255193; AI327365; C1S; C1s1; C1sa; r-gsp

View more View less

UniProt ID: (Human) P09871, (Rat) Q6P6T1, (Mouse) Q8CG14

View more View less

Entrez Gene ID: (Human) 716, (Rat) 192262, (Mouse) 50908

View more View less

Function(s)

serine-type endopeptidase activity calcium ion binding protein binding identical protein binding molecular_function peptidase activity serine-type peptidase activity hydrolase activity metal ion binding serine protease

Process(es)

proteolysis complement activation complement activation, classical pathway innate immune response glial cell differentiation response to cAMP immune system process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

C1S Polyclonal Antibody

C1S Antibody (14554-1-AP) in IHC (P)

Product Details

14554-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!