Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
21506-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C1orf106 Fusion Protein Ag15987 (314-663 aa encoded by BC106877)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PERAPVQNS PWKETSLDHP YEKPRKSSEP WSESSSPATT PQDGPSASSL WLLEPASYHV VPIRGVPGQW QGRTSAPATP EIQGRRGQSQ SLRVDSFRAG PEGRGRSAFP RRRPTHYTVT VPDSCFPATK PPLPHAACHS CSEDSGSDVS SISHPTSPGS SSPDISFLQP LSPPKTHRHR GAWVPAGSRE LVAHHPKLLL PPGYFPAGRY VVVAESPLPP GEWELCRAAP GPAYEEEGTP LRYQRLVPSR SRIVRTPSLK DSPAGRGLSK AAVSEELKWW HERARLRSTR PHSLDRQGAF RVRSLPLGRE GFGRALGPRA QVPTVCVLRR SPDGAPVQVF VPEKGEIISQ V (314-663 aa encoded by BC106877)
Target Information
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Innate immunity activator protein; uncharacterized protein C1orf106 homolog
Gene Aliases: 1700034M08Rik; 4933426C09Rik; AI586180; C1orf106; D1Mgi54; INAVA
UniProt ID: (Mouse) Q7TN12, (Human) Q3KP66
Entrez Gene ID: (Mouse) 67313, (Human) 55765, (Rat) 289399
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support