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FIGURE: 1 / 1
C1orf57 Antibody (PA5-75971) in WB
Western blot analysis of C1orf57 in Lane 1: HCT116 whole cell lysate (40 µg), Lane 2: HCC827 whole cell lysate (40 µg), Lane 3: L02 whole cell lysate (40 µg), Lane 4: SK-OVCAR3 whole cell lysate (40 µg). Samples were incubated with C1orf57 polyclonal antibody (Product # PA5-75971) at a dilution of 1:500.
Product Details
PA5-75971
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 145-189 of Human C1orf57
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719699
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Target Information
Belonging to the THEP1 NTPase family, C1orf57 (also known as nucleoside triphosphate phosphohydrolase), and its mouse homolog, 2310079N02Rik, are 190 amino acid proteins that has nucleotide phosphatase activity towards ATP, GTP, TTP, CTP and UTP. Acting as a monomer, it also hydrolyzes nucleoside diphosphates with lower efficiency. The gene encoding C1orf57 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer-related nucleoside-triphosphatase; Cancer-related nucleoside-triphosphatase homolog; NTPase; Nucleoside triphosphate phosphohydrolase; nucleoside-triphosphatase C1orf57 homolog; RP4-659I19.2; RP4-678E16.2
Gene Aliases: 2310079N02Rik; AI449709; C1orf57; HCR-NTPase; NTPCR; RGD1306192
UniProt ID: (Human) Q9BSD7, (Mouse) Q9CQA9
Entrez Gene ID: (Human) 84284, (Mouse) 66566, (Rat) 361443
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