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Product Details
26279-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C8orf4 Fusion Protein Ag23930 (1-106 aa encoded by BC021672)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKAKRSHQA IIMSTSLRVS PSIHGYHFDT ASRKKAVGNI FENTDQESLE RLFRNSGDKK AEERAKIIFA IDQDVEEKTR ALMALKKRTK DKLFQFLKLR KYSIKVH (1-106 aa encoded by BC021672)
Target Information
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human thyroid cancer 1; TC-1; Thyroid cancer protein 1; thyroid cancer-1; Transcriptional and immune response regulator; uncharacterized protein C8orf4 homolog
Gene Aliases: 1110065B09Rik; AW121743; AW321058; C8orf4; TC-1; TC1; TCIM
UniProt ID: (Mouse) Q9D915, (Human) Q9NR00
Entrez Gene ID: (Mouse) 69068, (Human) 56892
apoptotic process
regulation of hemopoiesis
endothelial cell activation involved in immune response
cellular response to heat
positive regulation of NF-kappaB import into nucleus
regulation of DNA-templated transcription in response to stress
negative regulation of Notch signaling pathway
regulation of cell cycle G1/S phase transition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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