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Product Details
BS-15289R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human C8orf4, amino acids 31-106.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human thyroid cancer 1; TC-1; Thyroid cancer protein 1; thyroid cancer-1; Transcriptional and immune response regulator; uncharacterized protein C8orf4 homolog
Gene Aliases: 1110065B09Rik; AW121743; AW321058; C8orf4; TC-1; TC1; TCIM
UniProt ID: (Mouse) Q9D915, (Human) Q9NR00
Entrez Gene ID: (Mouse) 69068, (Human) 56892
apoptotic process
regulation of hemopoiesis
endothelial cell activation involved in immune response
cellular response to heat
positive regulation of NF-kappaB import into nucleus
regulation of DNA-templated transcription in response to stress
negative regulation of Notch signaling pathway
regulation of cell cycle G1/S phase transition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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