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Product Details
12009-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CAMP Fusion Protein Ag2622 (1-170 aa encoded by BC055089)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize all the proprotein and cleaved species.
Immunogen sequence: MKTQRDGHS LGRWSLVLLL LGLVMPLAII AQVLSYKEAV LRAIDGINQR SSDANLYRLL DLDPRPTMDG DPDTPKPVSF TVKETVCPRT TQQSPEDCDF KKDGLVKRCM GTVTLNQARG SFDISCDKDN KRFALLGDFF RKSKEKIGKE FKRIVQRIKD FLRNLVPRTE S (1-170 aa encoded by BC055089)
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAP-18; Cathelicidin antimicrobial peptide; Cathelin-like protein; cathelin-related antimicrobial peptide; CLP; hCAP-18; hCAP18
Gene Aliases: CAMP; CAP-18; CAP18; Cnlp; CRAMP; FALL-39; FALL39; HSD26; LL37; MCLP
UniProt ID: (Human) P49913, (Mouse) P51437
Entrez Gene ID: (Human) 820, (Mouse) 12796
innate immune response in mucosa
antibacterial humoral response
defense response to bacterium
negative regulation of growth of symbiont on or near host surface
cell redox homeostasis
defense response to Gram-positive bacterium
killing by host of symbiont cells
positive regulation of protein phosphorylation
defense response
positive regulation of cell proliferation
negative regulation of growth of symbiont in host
positive regulation of angiogenesis
defense response to Gram-negative bacterium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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