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Product Details
PA5-29702
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 25 and 275 of Human CARD11
Conjugate
Form
Liquid
Concentration
1.02 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547176
Product Specific Information
Recommended positive controls: Raji, K562, NCI-H929, BCL-1.
Predicted reactivity: Mouse (96%), Chicken (87%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bcl10-interacting maguk protein 3; CARD-containing MAGUK protein 1; Carma 1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Aliases: 0610008L17Rik; 2410011D02Rik; BENTA; BIMP3; CARD11; CARMA1; IMD11; PPBL
UniProt ID: (Human) Q9BXL7, (Mouse) Q8CIS0
Entrez Gene ID: (Human) 84433, (Mouse) 108723
positive regulation of cytokine production
signal transduction
positive regulation of B cell proliferation
T cell costimulation
positive regulation of T cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
thymic T cell selection
positive regulation of interleukin-2 biosynthetic process
regulation of B cell differentiation
regulation of T cell differentiation
regulation of immune response
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
stimulatory C-type lectin receptor signaling pathway
Fc-epsilon receptor signaling pathway
GMP metabolic process
GDP metabolic process
T cell receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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