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Product Details
A300-198A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 350 and the C-terminus (residue 391) of human Casein Kinase 2, alpha 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 or Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Rabbit
Target Information
CSNK2A1 is a serine/threonine protein kinase that phosphorylates acidic proteins. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by CK2 alpha-1 represents the alpha subunit. While CK2 alpha-1 is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for CK2 alpha-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 2 alpha; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; Casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; casein kinase II, alpha 1 related sequence 4; CK II alpha; CK II alpha 3; CK2 catalytic subunit alpha; protein kinase CK2
Gene Aliases: CK2A1; CKII; Ckiia; CSNK2A1; Csnk2a1-rs4; CSNK2A3
UniProt ID: (Human) P68400, (Mouse) Q60737
Entrez Gene ID: (Human) 1457, (Mouse) 12995
protein phosphorylation
positive regulation of cell proliferation
positive regulation of Wnt signaling pathway
positive regulation of cell growth
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of protein catabolic process
protein autophosphorylation
regulation of catalytic activity
mitotic spindle checkpoint
transcription, DNA-templated
regulation of transcription, DNA-templated
protein folding
apoptotic process
signal transduction
Wnt signaling pathway
rhythmic process
chaperone-mediated protein folding
regulation of signal transduction by p53 class mediator
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