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Product Details
CL488-67868
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A6G6
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LALQLEQLLN PRPSEADPEA DPEEATAARV IDRFDEGEDG EGDFLVVGSI RKLASASLLD TDKRYCGKTT SRKAWNEDHW EQTLPGSSDE EISDEEGSGD EDSEGLGLEE YDEDDLGAAE EQECGDHRES KKSRSHSAKT PGFSVQSISD FEKFTKGMDD LGSSEEEEDE ESGMEEGDDA EDSQGESEED RAGDRNSEDD GVVMTF
Target Information
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-antagonizing transcription factor; Protein AATF; Rb-binding protein Che-1; Traube protein
Gene Aliases: 4933415H02Rik; 5830465M17Rik; AATF; BFR2; CHE-1; CHE1; DED; HSPC277; Trb
UniProt ID: (Human) B3KQ26, (Mouse) Q9JKX4, (Rat) Q9QYW0
Entrez Gene ID: (Human) 26574, (Mouse) 56321, (Rat) 114512
cellular response to DNA damage stimulus
cell adhesion
regulation of mitotic cell cycle
negative regulation of superoxide anion generation
embryonic cleavage
ribosome biogenesis
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of reactive oxygen species metabolic process
positive regulation of transcription, DNA-templated
apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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