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Product Details
OSC00044W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from rat Cathelicidin antimicrobial peptide conjugated to blue carrier protein has been used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Cathelicidin antimicrobial peptide.
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cathelicidin antimicrobial peptide; cathelin-related antimicrobial peptide; hCAP-18; hCAP18
Gene Aliases: CRAMP
Entrez Gene ID: (Rat) 316010
positive regulation of protein phosphorylation
innate immune response in mucosa
positive regulation of cell proliferation
negative regulation of endopeptidase activity
antibacterial humoral response
negative regulation of growth of symbiont in host
negative regulation of growth of symbiont on or near host surface
positive regulation of angiogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
killing by host of symbiont cells
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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