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Product Details
PA5-120383
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 132-170 of human CAMP (NP_004336.3).
Conjugate
Form
Liquid
Concentration
4.1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2913955
Product Specific Information
Positive test controls include: MCF7, A-549, PC-3, SP2/0, mouse testis, mouse spleen. The target is usually found in the following locations: Secreted.
Immunogen sequence: NKRFALLGDF FRKSKEKIGK EFKRIVQRIK DFLRNLVPR
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAP-18; Cathelicidin antimicrobial peptide; cathelin-related antimicrobial peptide; hCAP-18; hCAP18
Gene Aliases: CAMP; CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
UniProt ID: (Human) P49913
Entrez Gene ID: (Human) 820, (Rat) 316010
innate immune response in mucosa
antibacterial humoral response
defense response to bacterium
negative regulation of growth of symbiont on or near host surface
cell redox homeostasis
defense response to Gram-positive bacterium
killing by host of symbiont cells
positive regulation of protein phosphorylation
positive regulation of cell proliferation
negative regulation of endopeptidase activity
negative regulation of growth of symbiont in host
positive regulation of angiogenesis
defense response to Gram-negative bacterium
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
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