Invitrogen

Complex I Monoclonal Antibody (18G12BC2)

2 References
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

43-8800

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

Assay-dependent
View 1 publication 1 publication

Immunoprecipitation (IP)

0.1-1.0 mg/mL
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

18G12BC2

Immunogen

Bovine Heart Complex I

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

IgG fraction

Storage buffer

HEPES buffered saline

Contains

0.02% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_2533543

Product Specific Information

Positive control: fibroblasts, HL-60 cells, tissue mitochondria.

Target Information

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson’s disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 13 kDa differentiation-associated protein; 13kDa differentiation-associated protein; 14.5b subunit of the NADH-ubiquinone dehydrogenase complex; 16 kDa precursor; 19 kDa; 24-kDa subunit of mitochondrial NADH dehydrogenase; ACP; Acyl carrier protein, mitochondrial; B17.2-like; B17.2L; Cell adhesion protein SQM1; Cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CI-13kD-A; CI-13kD-B; CI-15 kDa; CI-18 kDa; CI-19kD; CI-20kD; CI-23kD; CI-30kD; CI-39kD; CI-42kD; CI-49kD; CI-51kD; CI-75kD; CI-9kD; CI-AGGG; CI-AQDQ; CI-ASHI; CI-B12; CI-B14; CI-B14.5a; CI-B14.5b; CI-B14.7; CI-B15; CI-B16.6; CI-B17; CI-B17.2; CI-B18; CI-B22; CI-B8; CI-B9; CI-ESSS; CI-KFYI; CI-MLRQ; CI-MNLL; CI-MWFE; CI-PDSW; CI-PGIV; CI-SDAP; CI-SGDH; CIB17.2; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 10kDa subunit; complex I 13kDa subunit A; complex I 13kDa subunit B; complex I 18kDa subunit; complex I 20kDa subunit; complex I 23kDa subunit; complex I 24kDa subunit; complex I 30kDa subunit; complex I 39kDa subunit; complex I 42kDa subunit; complex I 49kDa subunit; complex I 51 kda subunit; complex I 51kDa subunit; complex I 75kDa subunit; Complex I 9kDa subunit; complex I AGGG subunit; complex I ASHI subunit; complex I B14 subunit; complex I B14.5a subunit; complex I B14.7 subunit; complex I B15 subunit; complex I B16.6 subunit; complex I B17.2 subunit; complex I B18 subunit; complex I B22 subunit; complex I B8 subunit; complex I B9 subunit; Complex I intermediate-associated protein 30, mitochondrial; complex I KFYI subunit; complex I MNLL subunit; complex I MWFE subunit; complex I NP17.3 subunit; complex I PDSW subunit; complex I SDAP subunit; complex I SGDH subunit; Complex I subunit B13; complex I subunit B14.5b; complex I, mitochondrial respiratory chain; complex I, mitochondrial respiratory chain, 10-kD subunit; complex I, mitochondrial respiratory chain, 13-kD subunit; complex I, mitochondrial respiratory chain, 20-KD subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; complex I, mitochondrial respiratory chain, B17 subunit; complex I, mitochondrial respitory chain, 24 kD subunit; Complex I-13kD-A; Complex I-13kD-B; Complex I-15 kDa; Complex I-18 kDa; Complex I-19kD; Complex I-20kD; Complex I-23kD; Complex I-30kD; Complex I-39kD; Complex I-42kD; Complex I-49kD; Complex I-51kD; Complex I-75kD; Complex I-9kD; Complex I-AGGG; Complex I-AQDQ; Complex I-ASHI; Complex I-B12; Complex I-B14; Complex I-B14.5a; Complex I-B14.5b; Complex I-B14.7; Complex I-B15; Complex I-B16.6; Complex I-B17; Complex I-B17.2; Complex I-B18; Complex I-B22; Complex I-B8; Complex I-B9; Complex I-ESSS; Complex I-KFYI; Complex I-MLRQ; Complex I-MNLL; Complex I-MWFE; Complex I-PDSW; Complex I-PGIV; Complex I-SGDH; Cytochrome c oxidase subunit NDUFA4; gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; Gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19; GRIM-19; HLC-1; hormone-regulated proliferation associated protein 20; hormone-regulated proliferation-associated 20 kDa protein; Hormone-regulated proliferation-associated protein of 20 kDa; Hormone-regulated proliferation-associated protein of 20 kDa homolog; hormone-regulated proliferation-associated protein, 20 kDa; Human lung cancer oncogene 1 protein; LYR motif-containing protein 3; LYR motif-containing protein 6; Mimitin; mimitin, mitochondrial; mitochondrial acyl carrier protein; mitochondrial NADH dehydrogenase ubiquinone flavoprotein 1; mitochondrial NADH oxidoreductase-like protein; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; mitochondrial NADH:ubiquinone oxidoreductase 51 kda subunit; mitochondrial NADH:ubiquinone oxidoreductase B14.7; mitochondrial NADH:ubiquinone oxidoreductase ESSS subunit; mitochondrial respiratory chain complex I (18-KD subunit); MMTN; Myc-induced mitochondria protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 (9 kDa, MLRQ); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4; NADH dehydrogenase (ubiquinone) 1 assembly factor 1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa; NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 (6kD, KFYI); NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; NADH dehydrogenase (ubiquinone) 42 kDa subunit; NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; NADH dehydrogenase (ubiquinone) complex I, assembly factor 4; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 2-like (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 5b, 15kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa; NADH dehydrogenase (ubiquinone) flavoprotein 3-like; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH dehydrogenase 1 alpha subcomplex, 1; NADH dehydrogenase 1 beta subcomplex 8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH dehydrogenase Fe-S protein 6; NADH dehydrogenase flavoprotein 1; NADH dehydrogenase flavoprotein 1; 24 kDa (FP); NADH dehydrogenase flavoprotein 2; NADH dehydrogenase subunit 1; NADH dehydrogenase subunit 2; NADH dehydrogenase subunit 3; NADH dehydrogenase subunit 4; NADH dehydrogenase subunit 4L; NADH dehydrogenase subunit 5; NADH dehydrogenase subunit 6; NADH dehydrogenase subunit II; NADH dehydrogenase ubiquinone Fe-S 8; NADH dehydrogenase ubiquinone flavoprotein 1; NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial; NADH dehydrogenase-ubiquinone 30 kDa subunit; NADH oxidoreductase subunit MWFE; NADH ubiquinone oxidoreductase; NADH ubiquinone oxidoreductase PDSW subunit (RH 16p13.3); NADH ubiquinone oxidoreductase subunit B13; NADH ubiquinone oxidoreductase subunit MWFE; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 1 alpha subcomplex, 6; NADH-ubiquinone oxidoreductase 1 alpha subcomplex, assembly factor 1; NADH-ubiquinone oxidoreductase 13 kDa-A subunit; NADH-ubiquinone oxidoreductase 13 kDa-B subunit; NADH-ubiquinone oxidoreductase 15 kDa subunit; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH-ubiquinone oxidoreductase 19 kDa subunit; NADH-ubiquinone oxidoreductase 20 kDa subunit; NADH-ubiquinone oxidoreductase 23 kDa subunit; NADH-ubiquinone oxidoreductase 24 kDa subunit; NADH-ubiquinone oxidoreductase 30 kDa subunit; NADH-ubiquinone oxidoreductase 39 kDa subunit; NADH-ubiquinone oxidoreductase 42 kDa subunit; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase 51 kDa subunit; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; NADH-ubiquinone oxidoreductase 9 kD subunit; NADH-ubiquinone oxidoreductase 9 kDa subunit; NADH-ubiquinone oxidoreductase 9.6 kDa subunit; NADH-ubiquinone oxidoreductase AGGG subunit; NADH-ubiquinone oxidoreductase ASHI subunit; NADH-ubiquinone oxidoreductase B12 subunit; NADH-ubiquinone oxidoreductase B14 subunit; NADH-ubiquinone oxidoreductase B15 subunit; NADH-ubiquinone oxidoreductase B16.6 subunit; NADH-ubiquinone oxidoreductase B17 subunit; NADH-ubiquinone oxidoreductase B18 subunit; NADH-ubiquinone oxidoreductase B22 subunit; NADH-ubiquinone oxidoreductase B8 subunit; NADH-ubiquinone oxidoreductase B9 subunit; NADH-ubiquinone oxidoreductase beta subunit, 6; NADH-ubiquinone oxidoreductase chain 1; NADH-ubiquinone oxidoreductase chain 2; NADH-ubiquinone oxidoreductase chain 3; NADH-ubiquinone oxidoreductase chain 4; NADH-ubiquinone oxidoreductase chain 4L; NADH-ubiquinone oxidoreductase chain 5; NADH-ubiquinone oxidoreductase chain 6; NADH-ubiquinone oxidoreductase complex; NADH-ubiquinone oxidoreductase ESSS subunit; NADH-ubiquinone oxidoreductase Fe-S protein 7; NADH-ubiquinone oxidoreductase flavoprotein 2; NADH-ubiquinone oxidoreductase flavoprotein 3; NADH-ubiquinone oxidoreductase flavoprotein 3, 10kD; NADH-ubiquinone oxidoreductase KFYI subunit; NADH-ubiquinone oxidoreductase MLRQ subunit; NADH-ubiquinone oxidoreductase MLRQ subunit homolog; NADH-ubiquinone oxidoreductase MNLL subunit; NADH-ubiquinone oxidoreductase MWFE subunit; NADH-ubiquinone oxidoreductase NDUFS2 subunit; NADH-ubiquinone oxidoreductase PDSW subunit; NADH-ubiquinone oxidoreductase SGDH subunit; NADH-ubiquinone oxidoreductase subunit B14.5a; NADH-ubiquinone oxidoreductase subunit B14.5b; NADH-ubiquinone oxidoreductase subunit B14.7; NADH-ubiquinone oxidoreductase subunit B17.2; NADH-ubiquinone oxidoreductase subunit CI-B8; NADH-ubiquinone reductase 24 kDa mitochondrial; NADH:ubiquinone oxidoreductase (complex 1); NADH:ubiquinone oxidoreductase 15 kDa IP subunit; NADH:ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase B15 subunit; NADH:ubiquinone oxidoreductase MLRQ subunit homolog; NADH:ubiquinone oxidoreductase NDUFS6 subunit; NADH:ubiquinone oxidoreductase PGIV subunit; NADH:ubiquinone oxidoreductase PSST subunit; NADH:ubiquinone oxidoreductase SDAP subunit; NADH:ubiquinone reductase precursor; ND4L; NDUFA12-like protein; ndufa9 {ECO:0000312|EMBL:AAH91192.1, ECO:0000312|RGD:1307307}; ndufs2 {ECO:0000312|EMBL:AAH82067.1}; NDUFV1; NDUFV2; Neuronal protein 15.6; Neuronal protein 17.3; Np15.6; Np17.3; nuclear protein 15.6; Nuclear protein E3-3; nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit; NUOMS; p15.6; Protein 2P1; Protein HRPAP20; PSST subunit; Renal carcinoma antigen NY-REN-4; RGD1560158; short chain dehydrogenase/reductase family 22E, member 1; Sperm flagella protein 3; TYKY subunit; type I dehydrogenase; ubiquinone reductase

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Gene Aliases: 0610006N12Rik; 0610007D05Rik; 0610010M09Rik; 0610011B04Rik; 0610033L03Rik; 1010001M04Rik; 1010001M12Rik; 1010001N11Rik; 1110002H15Rik; 1110007M04Rik; 1190008J14Rik; 1300010H20Rik; 14.5kDa; 14kDa; 1500032D16Rik; 1700022J01Rik; 1810004I06Rik; 1810011O01Rik; 1810049F12Rik; 1810058I14Rik; 2010012C24Rik; 2010300P09Rik; 2210401F17Rik; 22kDa; 2310016K22Rik; 2310039H15Rik; 2400007M02Rik; 2410001M24Rik; 2410011G03Rik; 2610003B19Rik; 2700033I16Rik; 2700038D15Rik; 2700054G14Rik; 2900002J19Rik; 2900010C23Rik; 2900010I05Rik; 2900053E13Rik; 2P1; 3000003G13Rik; 4733401H18Rik; 5830412M15Rik; 6720411N02Rik; 8kDa; 9130423F15Rik; 9930026A05Rik; Aa2-258; ACP; AGGG; AI256693; AI325567; AI415450; AI987932; AL033311; AQDQ; ASHI; AU015782; AU022060; AV000592; AV006275; AW112974; AW214064; AW261656; B12; B13; B14; B14.5a; B14.5b; B14.7; B15; B16.6; B17; B17.2; B17.2L; B18; B22; B230217P19Rik; B8; B9; bA22L21.1; BC021616; BC059730; BC064011; C1-18k; C1-B8; C22H3orf60; C3orf60; C6orf66; C86051; C9H6ORF66; CC6; CD14; CDA016; CGI-39; CGI-65; CGI65; CI; CI-10k; CI-13kA; CI-13kB; CI-13kD-A; CI-13KD-B; CI-15k; CI-18; CI-18 kDa; CI-19KD; CI-20; CI-20KD; CI-23k; CI-23kD; CI-24k; CI-30; CI-30kD; CI-39k; CI-42k; CI-42KD; CI-49; CI-51K; CI-51kD; CI-75k; CI-75Kd; CI-9k; CI-9KD; CI-AGGG; CI-AQDQ; CI-ASHI; CI-B12; CI-B14; CI-B14-5A; CI-B14.5a; CI-B14.5b; CI-B14.7; CI-B15; CI-B18; CI-B22; CI-B8; CI-B9; CI-ESSS; CI-KFYI; CI-MLRQ; CI-MNLL; CI-MWFE; CI-PGIV; CI-SDAP; CI-SGDH; CI13KDA; CI15K; CI23KD; CI39k; CI51KD; CIA30; CIB8; CISGDH; D5Bwg0566e; D5Bwg0577e; DAP13; E3-3; ESSS; FASN2A; G1; Gm137; GRIM-19; GRIM19; HLC-1; HLC1; HRPAP20; HSPC125; IP13; Ip13dis; KFYI; LSDMCA3; LYRM3; LYRM6; mimitin; Mipp65; MLRQ; MMTN; MNLL; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND4L; MT-ND5; MT-ND6; MTND1; MTND2; MTND3; MTND4; MTND4L; MTND5; MTND6; MWFE; My013; MY017; NADH1; NADH2; NADH3; NADH4; NADH4L; NADH5; NADH6; NADHB14; NADHDH2; NADHUO; ND1; ND2; ND3; ND4; ND4L; ND5; ND6; Ndub13; NDUFA1; NDUFA10; ndufa10l; NDUFA11; NDUFA12; NDUFA12L; NDUFA13; NDUFA2; NDUFA3; NDUFA4; NDUFA4L2; NDUFA5; NDUFA6; NDUFA7; NDUFA8; NDUFA9; NDUFAB1; NDUFAF1; NDUFAF2; NDUFAF3; NDUFAF4; NDUFB1; NDUFB10; NDUFB11; NDUFB2; NDUFB3; NDUFB4; NDUFB5; NDUFB6; NDUFB7; NDUFB8; NDUFB9; NDUFC1; NDUFC2; NDUFS1; NDUFS2; NDUFS2L; NDUFS3; NDUFS4; NDUFS5; Ndufs5b; NDUFS6; NDUFS7; NDUFS8; NDUFV1; NDUFV2; NDUFV3; Ndufv3l; Np15; NP15.6; NP17.3; NUFM; NUOMS; P17.3; PDSW; PGIV; PRO1304; PSST; R75094; RATIp13dis; RGD1311462; RGD1560158; RGD1560955; RGD1563698; RGD708545; SDAP; SDR22E1; SGDH; TYKY; UNQ111/PRO1064; UQOR1; UQOR13; UQOR22; ZNF183

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UniProt ID: (Rat) P05506, (Mouse) P03899, (Mouse) P03925, (Bovine) Q02377, (Human) O15239, (Human) O95299, (Bovine) P34942, (Bovine) Q8HXG6, (Human) Q86Y39, (Human) Q9UI09, (Bovine) O97725, (Human) Q9P0J0, (Bovine) Q95KV7, (Human) O43678, (Bovine) Q02370, (Bovine) Q02371, (Human) O95167, (Bovine) Q01321, (Human) O00483, (Bovine) Q3SZ44, (Human) Q9NRX3, (Bovine) P23935, (Human) Q16718, (Bovine) Q02366, (Human) P56556, (Bovine) Q05752, (Human) O95182, (Bovine) P42029, (Human) P51970, (Human) Q16795, (Bovine) P34943, (Human) O14561, (Bovine) P52505, (Human) Q9Y375, (Human) Q8N183, (Bovine) Q32P65, (Human) Q9BU61, (Bovine) Q2HJI2, (Bovine) A4FUH5, (Human) Q9P032, (Bovine) Q02378, (Human) O75438, (Human) O96000, (Bovine) Q02373, (Bovine) Q8HXG5, (Human) Q9NX14, (Bovine) Q02374, (Human) O95178, (Bovine) Q02365, (Human) O43676, (Bovine) P48305, (Human) O95168, (Bovine) Q02380, (Human) O43674, (Human) O95139, (Bovine) Q02367, (Human) P17568, (Bovine) Q02368, (Human) O95169, (Bovine) Q02372, (Human) Q9Y6M9, (Bovine) Q02369, (Bovine) Q02376, (Human) O43677, (Bovine) Q02827, (Human) O95298, (Bovine) P15690, (Human) P28331, (Human) O75306, (Bovine) P17694, (Bovine) P23709, (Human) O75489, (Bovine) Q02375, (Human) O43181, (Bovine) Q02379, (Human) O43920, (Bovine) P23934, (Human) O75380, (Human) O75251, (Bovine) P42026, (Human) O00217, (Bovine) P42028, (Human) P49821, (Bovine) P25708, (Human) P19404, (Bovine) P04394, (Human) P56181, (Bovine) P25712, (Mouse) O35683, (Rat) Q561S0, (Mouse) Q99LC3, (Rat) Q80W89, (Mouse) Q7TMF3, (Mouse) Q9ERS2, (Mouse) Q9CQ75, (Mouse) Q9CQ91, (Mouse) Q62425, (Mouse) Q4FZG9, (Mouse) Q9CPP6, (Rat) Q63362, (Mouse) Q9CQZ5, (Mouse) Q9Z1P6, (Mouse) Q9DCJ5, (Rat) Q5BK63, (Mouse) Q9DC69, (Mouse) Q9CR21, (Mouse) Q9CWX2, (Mouse) Q59J78, (Mouse) Q9JKL4, (Rat) O08776, (Mouse) Q9D1H6, (Rat) Q9NQR8, (Mouse) Q9DCS9, (Mouse) O09111, (Mouse) Q9CPU2, (Mouse) Q9CQZ6, (Mouse) Q9CQC7, (Mouse) Q9CQH3, (Mouse) Q3UIU2, (Mouse) Q9CR61, (Mouse) Q9D6J5, (Mouse) Q9CQJ8, (Mouse) Q9CQY9, (Mouse) Q9CQ54, (Mouse) Q91VD9, (Rat) Q66HF1, (Rat) Q641Y2, (Mouse) Q91WD5, (Mouse) Q9DCT2, (Rat) Q5XIF3, (Mouse) Q9CXZ1, (Mouse) Q99LY9, (Mouse) P52503, (Mouse) Q9DC70, (Mouse) Q8K3J1, (Mouse) Q91YT0, (Rat) P19234, (Mouse) Q9D6J6, (Mouse) Q8BK30, (Rat) Q6PCU8

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Entrez Gene ID: (Rat) 100911483, (Rat) 26199, (Mouse) 17718, (Mouse) 17722, (Bovine) 327673, (Human) 4694, (Human) 4705, (Bovine) 338060, (Bovine) 326346, (Human) 126328, (Human) 55967, (Bovine) 281742, (Human) 51079, (Bovine) 338084, (Human) 4695, (Bovine) 327698, (Bovine) 338064, (Human) 4696, (Bovine) 327704, (Human) 4697, (Bovine) 613541, (Human) 56901, (Bovine) 327714, (Human) 4698, (Bovine) 327670, (Human) 4700, (Bovine) 338063, (Human) 4701, (Bovine) 327710, (Human) 4702, (Human) 4704, (Bovine) 404188, (Human) 4706, (Bovine) 327702, (Human) 51103, (Bovine) 541232, (Human) 91942, (Bovine) 767961, (Human) 25915, (Bovine) 511968, (Bovine) 615440, (Human) 29078, (Bovine) 327690, (Human) 4707, (Human) 4716, (Bovine) 327701, (Bovine) 404161, (Human) 54539, (Bovine) 327713, (Human) 4708, (Bovine) 338073, (Human) 4709, (Bovine) 327706, (Human) 4710, (Bovine) 338061, (Human) 4711, (Human) 4712, (Bovine) 327665, (Human) 4713, (Bovine) 338065, (Human) 4714, (Bovine) 282517, (Human) 4715, (Bovine) 327660, (Bovine) 282289, (Human) 4717, (Bovine) 338046, (Human) 4718, (Bovine) 288380, (Human) 4719, (Human) 4720, (Bovine) 327697, (Bovine) 287327, (Human) 4722, (Bovine) 327680, (Human) 4724, (Bovine) 338057, (Human) 4725, (Bovine) 327691, (Human) 4726, (Human) 374291, (Bovine) 338079, (Human) 4728, (Bovine) 287027, (Human) 4723, (Bovine) 287014, (Human) 4729, (Bovine) 282290, (Human) 4731, (Bovine) 327717, (Mouse) 54405, (Rat) 363441, (Rat) 678759, (Mouse) 67273, (Mouse) 69875, (Rat) 301123, (Mouse) 66414, (Rat) 299739, (Mouse) 67184, (Mouse) 17991, (Rat) 291660, (Rat) 691001, (Mouse) 66091, (Mouse) 17992, (Rat) 681024, (Rat) 100362331, (Mouse) 407790, (Mouse) 68202, (Rat) 25488, (Rat) 315167, (Mouse) 67130, (Rat) 299643, (Mouse) 66416, (Mouse) 68375, (Rat) 296658, (Rat) 362440, (Mouse) 66108, (Rat) 293453, (Mouse) 70316, (Rat) 296086, (Mouse) 69702, (Rat) 361894, (Mouse) 75597, (Mouse) 66706, (Rat) 56769, (Mouse) 68493, (Rat) 362495, (Mouse) 68342, (Rat) 681418, (Rat) 299310, (Mouse) 104130, (Rat) 362344, (Mouse) 68198, (Mouse) 66495, (Rat) 301427, (Mouse) 68194, (Rat) 288088, (Mouse) 66046, (Rat) 294964, (Rat) 297990, (Mouse) 230075, (Mouse) 66916, (Rat) 361385, (Rat) 293991, (Mouse) 67264, (Rat) 299954, (Mouse) 66218, (Rat) 689938, (Mouse) 66377, (Rat) 293130, (Mouse) 68197, (Mouse) 227197, (Rat) 301458, (Rat) 289218, (Mouse) 226646, (Rat) 295923, (Mouse) 68349, (Rat) 499529, (Mouse) 17993, (Rat) 362588, (Mouse) 595136, (Mouse) 407785, (Rat) 29478, (Rat) 362837, (Mouse) 75406, (Rat) 293652, (Mouse) 225887, (Mouse) 17995, (Rat) 293655, (Rat) 81728, (Mouse) 72900, (Mouse) 78330, (Rat) 64539

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Function(s)
NADH dehydrogenase (ubiquinone) activity electron carrier activity NADH dehydrogenase activity protein binding ATP binding cytochrome-c oxidase activity protein complex binding structural constituent of ribosome oxidoreductase activity macromolecular complex binding coenzyme binding ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process fatty acid binding calcium ion binding unfolded protein binding calmodulin binding metal ion binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding ubiquitin protein ligase binding quinone binding NAD binding protease binding oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor FMN binding poly(A) RNA binding molecular_function nucleoside kinase activity oxidoreductase activity, acting on NAD(P)H iron-sulfur cluster binding dehydrogenase oxidoreductase metabolite interconversion enzyme transfer/carrier protein nucleotide kinase chaperone reductase
Process(es)
mitochondrial respiratory chain complex I assembly oxidation-reduction process mitochondrial electron transport, NADH to ubiquinone response to drug response to oxidative stress respiratory gaseous exchange electron transport chain positive regulation of peptidase activity negative regulation of cell growth cellular response to interferon-beta positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein import into mitochondrial inner membrane positive regulation of protein catabolic process negative regulation of transcription, DNA-templated cellular response to retinoic acid reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway hydrogen ion transmembrane transport mitochondrial electron transport, cytochrome c to oxygen mitochondrial translation ATP synthesis coupled electron transport sodium ion transport ubiquinone-6 biosynthetic process circadian rhythm fatty acid biosynthetic process protein lipoylation glyoxylate metabolic process protein complex assembly respiratory electron transport chain cellular respiration negative regulation of insulin secretion involved in cellular response to glucose stimulus sensory perception of sound mitophagy in response to mitochondrial depolarization apoptotic mitochondrial changes ATP metabolic process regulation of mitochondrial membrane potential substantia nigra development regulation of protein phosphorylation brain development cAMP-mediated signaling positive regulation of fibroblast proliferation response to cAMP fatty acid metabolic process muscle contraction multicellular organism aging multicellular organism growth reproductive system development mitochondrion morphogenesis cardiovascular system development aerobic respiration nervous system development cardiac muscle tissue development transport nucleotide biosynthetic process nucleobase-containing compound metabolic process biological_process response to glucose lipid metabolic process positive regulation of cell proliferation NADH dehydrogenase complex assembly negative regulation of apoptotic process
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