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AbboMax
Cyclic adenosine monophosphate (cAMP) Monoclonal Antibody (ABM486), Biotin
FIGURE: 1 / 1
Cyclic adenosine monophosphate (cAMP) Antibody (500-953B) in IHC (P)
Immunohistochemistry: Human Lung carcinoma (FFPE) stained with Mouse anti-cAMP-Biotinylated(Cat#500-953B ) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
500-953B
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
ABM486
Immunogen
A chemically linked 3, 5-Cyclic Adenosine Monophosphate (cAMP)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: C-AMP-BSA
Cellular location: Cytoplasmic.
Target Information
Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAP-18; Cathelicidin antimicrobial peptide; Cathelin-like protein; cathelin-related antimicrobial peptide; CLP; Cyclic AMP
Gene Aliases: CAMP; CAP-18; CAP18; Cnlp; CRAMP; FALL-39; FALL39; HSD26; LL37; MCLP
UniProt ID: (Human) P49913, (Mouse) P51437
Entrez Gene ID: (Human) 820, (Rat) 316010, (Mouse) 12796
innate immune response in mucosa
antibacterial humoral response
defense response to bacterium
negative regulation of growth of symbiont on or near host surface
cell redox homeostasis
defense response to Gram-positive bacterium
killing by host of symbiont cells
positive regulation of protein phosphorylation
positive regulation of cell proliferation
negative regulation of endopeptidase activity
negative regulation of growth of symbiont in host
positive regulation of angiogenesis
defense response to Gram-negative bacterium
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
defense response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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