Proteintech

Cyclophilin B Polyclonal Antibody

Cyclophilin B Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 18

Cyclophilin B Antibody (11607-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 11607-1-AP (Cyclophilin B antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Cyclophilin B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cyclophilin B Antibody in Western Blot (WB)

Product Image Gallery

Product Details

11607-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cyclophilin B Fusion Protein Ag2161 (1-216 aa encoded by BC032138)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLRLSERNM KVLLAAALIA GSVFFLLLPG PSAADEKKKG PKVTVKVYFD LRIGDEDVGR VIFGLFGKTV PKTVDNFVAL ATGEKGFGYK NSKFHRVIKD FMIQGGDFTR GDGTGGKSIY GERFPDENFK LKHYGPGWVS MANAGKDTNG SQFFITTVKT AWLDGKHVVF GKVLEGMEVV RKVESTKTDS RDKPLKDVII ADCGKIEVEK PFAIAKE (1-216 aa encoded by BC032138)

Target Information

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Isolation and short-term culturing of primary lymphatic endothelial cells from collecting lymphatics: A techniques study.

Microcirculation (New York, N.Y. : 1994)

Jablon KL,Akerstrom VL,Li M,Braun SE,Norton CE,Castorena-Gonzalez JA

Sat Apr 01 00:00:00 EDT 2023

OGG1 aggravates renal ischemia-reperfusion injury by repressing PINK1-mediated mitophagy.

Cell proliferation

Zhao F,Zhu J,Zhang M,Luo Y,Li Y,Shi L,Huang J,Shadekejiang H,Dong S,Wu X

Tue Aug 01 00:00:00 EDT 2023

HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy.

Cells

Shi L,Song Z,Li C,Deng F,Xia Y,Huang J,Wu X,Zhu J

Wed Dec 07 00:00:00 EST 2022

RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.

International immunopharmacology

Zhu J,Zhang Y,Shi L,Xia Y,Zha H,Li H,Song Z

Mon Aug 01 00:00:00 EDT 2022

Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate.

Disease models & mechanisms

Besio R,Garibaldi N,Leoni L,Cipolla L,Sabbioneda S,Biggiogera M,Mottes M,Aglan M,Otaify GA,Temtamy SA,Rossi A,Forlino A

Thu Jun 20 00:00:00 EDT 2019

Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations.

Cellular and molecular life sciences : CMLS

Wu J,Zhang W,Xia L,Feng L,Shu Z,Zhang J,Ye W,Zeng N,Zhou A

Tue Oct 01 00:00:00 EDT 2019

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Molecular cell

Chen PH,Cai L,Huffman K,Yang C,Kim J,Faubert B,Boroughs L,Ko B,Sudderth J,McMillan EA,Girard L,Chen D,Peyton M,Shields MD,Yao B,Shames DS,Kim HS,Timmons B,Sekine I,Britt R,Weber S,Byers LA,Heymach JV,Chen J,White MA,Minna JD,Xiao G,DeBerardinis RJ

Thu Dec 05 00:00:00 EST 2019

Proteomic methods reveal cyclophilin A function as a host restriction factor against rotavirus infection.

Proteomics

He H,Mou Z,Li W,Fei L,Tang Y,Zhang J,Yan P,Chen Z,Yang X,Shen Z,Li J,Wu Y

Mon Apr 01 00:00:00 EDT 2013

Proteomic methods reveal cyclophilin A function as a host restriction factor against rotavirus infection.

Proteomics

He H,Mou Z,Li W,Fei L,Tang Y,Zhang J,Yan P,Chen Z,Yang X,Shen Z,Li J,Wu Y

Mon Apr 01 00:00:00 EDT 2013

Synchronous detection of miRNAs, their targets and downstream proteins in transferred FFPE sections: applications in clinical and basic research.

Methods (San Diego, Calif.)

Zhao JY,Liu CQ,Zhao HN,Ding YF,Bi T,Wang B,Lin XC,Guo G,Cui SY

Mon Oct 01 00:00:00 EDT 2012

Synchronous detection of miRNAs, their targets and downstream proteins in transferred FFPE sections: applications in clinical and basic research.

Methods (San Diego, Calif.)

Zhao JY,Liu CQ,Zhao HN,Ding YF,Bi T,Wang B,Lin XC,Guo G,Cui SY

Mon Oct 01 00:00:00 EDT 2012

Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.

Human molecular genetics

Pyott SM,Schwarze U,Christiansen HE,Pepin MG,Leistritz DF,Dineen R,Harris C,Burton BK,Angle B,Kim K,Sussman MD,Weis M,Eyre DR,Russell DW,McCarthy KJ,Steiner RD,Byers PH

Fri Apr 15 00:00:00 EDT 2011

Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.

Human molecular genetics

Pyott SM,Schwarze U,Christiansen HE,Pepin MG,Leistritz DF,Dineen R,Harris C,Burton BK,Angle B,Kim K,Sussman MD,Weis M,Eyre DR,Russell DW,McCarthy KJ,Steiner RD,Byers PH

Fri Apr 15 00:00:00 EDT 2011

Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.

Human molecular genetics

Pyott SM,Schwarze U,Christiansen HE,Pepin MG,Leistritz DF,Dineen R,Harris C,Burton BK,Angle B,Kim K,Sussman MD,Weis M,Eyre DR,Russell DW,McCarthy KJ,Steiner RD,Byers PH

Fri Apr 15 00:00:00 EDT 2011

Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.

Human molecular genetics

Pyott SM,Schwarze U,Christiansen HE,Pepin MG,Leistritz DF,Dineen R,Harris C,Burton BK,Angle B,Kim K,Sussman MD,Weis M,Eyre DR,Russell DW,McCarthy KJ,Steiner RD,Byers PH

Fri Apr 15 00:00:00 EDT 2011

CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

Journal of virology

Watanabe A,Yoneda M,Ikeda F,Terao-Muto Y,Sato H,Kai C

Sat May 01 00:00:00 EDT 2010

CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

Journal of virology

Watanabe A,Yoneda M,Ikeda F,Terao-Muto Y,Sato H,Kai C

Sat May 01 00:00:00 EDT 2010

CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

Journal of virology

Watanabe A,Yoneda M,Ikeda F,Terao-Muto Y,Sato H,Kai C

Sat May 01 00:00:00 EDT 2010

CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

Journal of virology

Watanabe A,Yoneda M,Ikeda F,Terao-Muto Y,Sato H,Kai C

Sat May 01 00:00:00 EDT 2010

PPIB mutations cause severe osteogenesis imperfecta.

American journal of human genetics

van Dijk FS,Nesbitt IM,Zwikstra EH,Nikkels PG,Piersma SR,Fratantoni SA,Jimenez CR,Huizer M,Morsman AC,Cobben JM,van Roij MH,Elting MW,Verbeke JI,Wijnaendts LC,Shaw NJ,Högler W,McKeown C,Sistermans EA,Dalton A,Meijers-Heijboer H,Pals G

Thu Oct 01 00:00:00 EDT 2009

PPIB mutations cause severe osteogenesis imperfecta.

American journal of human genetics

Thu Oct 01 00:00:00 EDT 2009

PPIB mutations cause severe osteogenesis imperfecta.

American journal of human genetics

Thu Oct 01 00:00:00 EDT 2009

PPIB mutations cause severe osteogenesis imperfecta.

American journal of human genetics

Thu Oct 01 00:00:00 EDT 2009

Modulated T-complex protein 1 ζ and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics.

Proteomics. Clinical applications

Yue F,Wang LS,Xia L,Wang XL,Feng B,Lu AG,Chen GQ,Zheng MH

Thu Oct 01 00:00:00 EDT 2009

Proteomics. Clinical applications

Yue F,Wang LS,Xia L,Wang XL,Feng B,Lu AG,Chen GQ,Zheng MH

Thu Oct 01 00:00:00 EDT 2009

Proteomics. Clinical applications

Yue F,Wang LS,Xia L,Wang XL,Feng B,Lu AG,Chen GQ,Zheng MH

Thu Oct 01 00:00:00 EDT 2009

Proteomics. Clinical applications

Yue F,Wang LS,Xia L,Wang XL,Feng B,Lu AG,Chen GQ,Zheng MH

Thu Oct 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: Cyclophilin B; cyclophilin-like protein; Cyp B; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; Rotamase B; S-cyclophilin; SCYLP

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Gene Aliases: AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b; CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP

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UniProt ID: (Human) P23284, (Mouse) P24369

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Entrez Gene ID: (Human) 5479, (Mouse) 19035

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Function(s)

peptidyl-prolyl cis-trans isomerase activity protein binding collagen binding protein complex binding peptide binding poly(A) RNA binding unfolded protein binding RNA polymerase binding isomerase activity chaperone

Process(es)

protein peptidyl-prolyl isomerization positive regulation of multicellular organism growth positive regulation by host of viral process positive regulation by host of viral genome replication protein stabilization bone development chaperone-mediated protein folding regulation of post-translational protein modification protein folding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cyclophilin B Polyclonal Antibody

Cyclophilin B Antibody (11607-1-AP) in ICC/IF

Product Details

11607-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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