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NeoBiotechnologies
DAZL (Deleted in Azoospermia-like) Monoclonal Antibody (DAZL/4253)
Product Details
1618-MSM1-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cynomolgus monkey,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
DAZL/4253
Immunogen
Recognizes DAZL protein C terminus sequence CRVHHFRRSRAMLKSV.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Wet ice
Target Information
Protein expression pattern show that DAZL is involved in mitosis and meiosis of human germ cell. The DAZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.The protein is expressed in germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DAZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DAZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DAZL transcripts were lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DAZ homologous gene function found to be azoospermic, just as with human azoospermia DAZ. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAZ homolog; DAZ-like autosomal; deleted in azoospermia protein 3; Deleted in azoospermia-like; Deleted in azoospermia-like 1; germline specific RNA binding protein; HGNC:2685; MGC26406; RNA-binding protein; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; testis secretory sperm-binding protein Li 204a
Gene Aliases: cynDAZLA; Daz-like; DAZH; DAZL; DAZL1; DAZLA; SPGYLA; Tpx-2; Tpx2
UniProt ID: (Human) Q92904, (Mouse) Q64368
Entrez Gene ID: (Cynomolgus monkey) 102121570, (Human) 1618, (Mouse) 13164, (Rat) 680486
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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