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Product Details
PA5-79139
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human DCC (162-178aa EVIGEPMPTIHWQKNQQ).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746255
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Colorectal cancer suppressor; colorectal tumor suppressor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; Netrin receptor DCC; putative colorectal tumor suppressor; Tumor suppressor protein DCC
Gene Aliases: C030036D22Rik; CRC18; CRCR1; DCC; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146, (Mouse) P70211, (Rat) Q63155
Entrez Gene ID: (Human) 1630, (Mouse) 13176, (Rat) 25311
neuron migration
apoptotic process
axonogenesis
axon guidance
negative regulation of neuron projection development
spinal cord ventral commissure morphogenesis
dorsal/ventral axon guidance
anterior/posterior axon guidance
netrin-activated signaling pathway
negative regulation of collateral sprouting
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neuron death
negative regulation of dendrite development
multicellular organism development
positive regulation of neuron projection development
positive regulation of ERK1 and ERK2 cascade
regulation of nucleic acid-templated transcription
response to amphetamine
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