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Product Details
PA5-85910
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein with of Human Netrin receptor DCC aa 21-299
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2802711
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Colorectal cancer suppressor; colorectal tumor suppressor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; Netrin receptor DCC; putative colorectal tumor suppressor; Tumor suppressor protein DCC
Gene Aliases: C030036D22Rik; CRC18; CRCR1; DCC; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146, (Mouse) P70211
Entrez Gene ID: (Human) 1630, (Mouse) 13176
neuron migration
apoptotic process
axonogenesis
axon guidance
negative regulation of neuron projection development
spinal cord ventral commissure morphogenesis
dorsal/ventral axon guidance
anterior/posterior axon guidance
netrin-activated signaling pathway
negative regulation of collateral sprouting
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neuron death
negative regulation of dendrite development
multicellular organism development
positive regulation of neuron projection development
positive regulation of ERK1 and ERK2 cascade
regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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