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This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
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Protein Aliases: ATP-dependent RNA helicase DHX8; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH (Asp-Glu-Ala-His) box polypeptide 8; DEAH box protein 8; RNA helicase; RNA helicase HRH1
Gene Aliases: DDX8; DHX8; HRH1; LRRGT00035; mDEAH6; mKIAA4096; PRP22; PRPF22
UniProt ID: (Human) Q14562, (Mouse) A2A4P0
Entrez Gene ID: (Human) 1659, (Mouse) 217207, (Rat) 287727
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