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DOK7 Antibody (PA5-115139) in IHC (P)
Immunohistochemistry analysis of DOK7 in human Heart muscle tissue sections. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115139) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Product Details
PA5-115139
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DOK7(Accession Q18PE1), corresponding to amino acid residues P415-T465.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899775
Product Specific Information
Antibody detects endogenous levels of total DOK7.
Target Information
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Downstream of tyrosine kinase 7; oncoprotein induced transcript 5; Protein Dok-7
Gene Aliases: A930013K19Rik; AW049091; C4orf25; CMS10; CMS1B; Dok-7; DOK7; EF-12; Oit5
UniProt ID: (Human) Q18PE1, (Mouse) Q18PE0
Entrez Gene ID: (Human) 285489, (Mouse) 231134
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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