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DP1 Antibody (PA5-99165) in ICC/IF
Immunofluorescent analysis of DP1 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with DP1 polyclonal antibody (Product # PA5-99165) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
Product Details
PA5-99165
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TFDP1(Accession Q14186), corresponding to amino acid residues A373-D410.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818098
Product Specific Information
Antibody detects endogenous levels of total TFDP1.
Target Information
DP family contains at least two members, DP1 and 2. Structurally, DP1 and 2 are relatively conserved, yet their expression appears to be tissue specific. E2F 1, a functional target for the tumor suppressor protein Rb, heterodimerizes with DP1 and forms an active E2F transcriptional complex. The interaction between members of the E2F and the DP families is mediated, in part, by a leucine repeat which is weakly conserved between the two families.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AS1; ASRT1; down-regulated in liver cancer stem cells; DRTF1; DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor; MGC49004; OTTHUMP00000018767; Transcription factor Dp-1
Gene Aliases: DILC; Dp-1; DP1; DRTF1; TFDP1
UniProt ID: (Human) Q14186
Entrez Gene ID: (Human) 7027, (Rat) 361178
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell proliferation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fat cell proliferation
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
mitotic cell cycle
regulation of transcription, DNA-templated
epidermis development
anoikis
positive regulation of transcription, DNA-templated
regulation of DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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