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This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.
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Protein Aliases: Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase 3; Dipeptidyl peptidase III; dipeptidyl-peptidase 3; dipeptidyl-peptidase III; dipeptidylpeptidase III; DPP III; Enkephalinase B; hCG_2016942
Gene Aliases: 4930533O14Rik; C86324; DPP3; DPPIII
UniProt ID: (Human) Q9NY33, (Rat) O55096, (Mouse) Q99KK7
Entrez Gene ID: (Human) 10072, (Rat) 114591, (Mouse) 75221
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