Bioss

DRD4 Polyclonal Antibody

View all (17) D4 Dopamine Receptor antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-1746R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human DRD4, amino acids 151-250.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor

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Gene Aliases: AW125663; D4DR; D4R; D4RA; Drd-4; DRD4

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UniProt ID: (Human) P21917, (Mouse) P51436

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Entrez Gene ID: (Human) 1815, (Rat) 25432, (Mouse) 13491

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gi/Go dopamine neurotransmitter receptor activity protein binding drug binding potassium channel regulator activity SH3 domain binding dopamine binding identical protein binding signal transducer activity G-protein coupled receptor activity G-protein coupled amine receptor activity G-protein coupled receptor
Process(es)
activation of MAPK activity behavioral fear response synaptic transmission, dopaminergic response to amphetamine cellular calcium ion homeostasis negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway short-term memory circadian rhythm adult locomotory behavior olfactory learning photoperiodism negative regulation of cAMP biosynthetic process positive regulation of sodium:proton antiporter activity positive regulation of kinase activity response to histamine social behavior regulation of dopamine metabolic process dopamine metabolic process fear response regulation of circadian rhythm regulation of neurotransmitter secretion behavioral response to cocaine behavioral response to ethanol response to steroid hormone arachidonic acid secretion negative regulation of protein secretion regulation of calcium-mediated signaling positive regulation of dopamine uptake involved in synaptic transmission retina development in camera-type eye inhibitory postsynaptic potential positive regulation of penile erection negative regulation of voltage-gated calcium channel activity positive regulation of excitatory postsynaptic potential locomotory behavior associative learning modulation of synaptic transmission signal transduction G-protein coupled receptor signaling pathway chemical synaptic transmission sensory perception of chemical stimulus rhythmic process
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