Proteintech

DRD5 Polyclonal Antibody

DRD5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DRD5 Antibody (20310-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 20310-1-AP) DRD5 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

20310-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DRD5 Fusion Protein Ag14145 (351-477 aa encoded by BC009748)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NSSLNPVIY AFNADFQKVF AQLLGCSHFC SRTPVETVNI SNELISYNQD IVFHKEIAAA YIHMMPNAVT PGNREVDNDE EEGPFDRMFQ IYQTSPDGDP VAESVWELDC EGEISLDKIT PFTPNGFH (351-477 aa encoded by BC009748)

Target Information

The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development.

Journal of the American Society of Nephrology : JASN

Gerhards J,Maerz LD,Matthees ESF,Donow C,Moepps B,Premont RT,Burkhalter MD,Hoffmann C,Philipp M

Sat Apr 01 00:00:00 EDT 2023

DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.

Cell death & disease

Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S

Mon May 17 00:00:00 EDT 2021

Increased AT₁ receptor expression mediates vasoconstriction leading to hypertension in Snx1^-/- mice.

Hypertension research : official journal of the Japanese Society of Hypertension

Liu C,Li X,Fu J,Chen K,Liao Q,Wang J,Chen C,Luo H,Jose PA,Yang Y,Yang J,Zeng C

Sun Aug 01 00:00:00 EDT 2021

Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review.

International journal of molecular sciences

Kurnik-Łucka M,Pasieka P,Łączak P,Wojnarski M,Jurczyk M,Gil K

Mon Nov 29 00:00:00 EST 2021

Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation.

Molecular cell

Wu Y,Hu Y,Wang B,Li S,Ma C,Liu X,Moynagh PN,Zhou J,Yang S

Thu Apr 02 00:00:00 EDT 2020

Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity.

Cellular oncology (Dordrecht)

Yang K,Wei M,Yang Z,Fu Z,Xu R,Cheng C,Chen X,Chen S,Dammer E,Le W

Tue Dec 01 00:00:00 EST 2020

Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity.

Cellular oncology (Dordrecht)

Yang K,Wei M,Yang Z,Fu Z,Xu R,Cheng C,Chen X,Chen S,Dammer E,Le W

Tue Dec 01 00:00:00 EST 2020

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice.

Journal of neurochemistry

Xu K,He Y,Chen X,Tian Y,Cheng K,Zhang L,Wang Y,Yang D,Wang H,Wu Z,Li Y,Lan T,Dong Z,Xie P

Sat Jun 01 00:00:00 EDT 2019

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice.

Journal of neurochemistry

Xu K,He Y,Chen X,Tian Y,Cheng K,Zhang L,Wang Y,Yang D,Wang H,Wu Z,Li Y,Lan T,Dong Z,Xie P

Sat Jun 01 00:00:00 EDT 2019

Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors.

ACS chemical neuroscience

Zhang G,Buchler IP,DePasquale M,Wormald M,Liao G,Wei H,Barrow JC,Carr GV

Wed Oct 16 00:00:00 EDT 2019

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.

Cell

Yan Y,Jiang W,Liu L,Wang X,Ding C,Tian Z,Zhou R

Thu Jan 15 00:00:00 EST 2015

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.

Cell

Yan Y,Jiang W,Liu L,Wang X,Ding C,Tian Z,Zhou R

Thu Jan 15 00:00:00 EST 2015

Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.

Neurotoxicology

Dervola KS,Johansen EB,Walaas SI,Fonnum F

Tue Sep 01 00:00:00 EDT 2015

Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.

Neurotoxicology

Dervola KS,Johansen EB,Walaas SI,Fonnum F

Tue Sep 01 00:00:00 EDT 2015

Vivo-morpholinos induced transient knockdown of physical activity related proteins.

PloS one

Ferguson DP,Schmitt EE,Lightfoot JT

Tue Nov 12 00:00:00 EST 2013

Vivo-morpholinos induced transient knockdown of physical activity related proteins.

PloS one

Ferguson DP,Schmitt EE,Lightfoot JT

Tue Nov 12 00:00:00 EST 2013

Bioinformatics

Protein Aliases: D(1B) dopamine receptor; D(5) dopamine receptor; D1b receptor; D1beta dopamine receptor; Dopamine 5 receptor; Dopamine D5 receptor; dopamine receptor 5; dopamine receptor D1B; DRD 1B; DRD 5; Hd5dr; MGC10601

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Gene Aliases: D1B; D5R; DBDR; Drd-5; DRD1B; DRD1L2; DRD5; Gpcr1

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UniProt ID: (Human) P21918, (Mouse) Q8BLD9, (Rat) P25115

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Entrez Gene ID: (Human) 1816, (Mouse) 13492, (Rat) 25195

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Function(s)

dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity dopamine binding G-protein alpha-subunit binding protein binding drug binding G-protein coupled receptor

Process(es)

synaptic transmission, dopaminergic response to amphetamine regulation of systemic arterial blood pressure by vasopressin norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure cellular calcium ion homeostasis adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-activating dopamine receptor signaling pathway chemical synaptic transmission learning associative learning positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway transmission of nerve impulse negative regulation of NAD(P)H oxidase activity wound healing response to cocaine positive regulation of adenylate cyclase activity negative regulation of blood pressure regulation of female receptivity sensitization phospholipase C-activating dopamine receptor signaling pathway long term synaptic depression cellular response to catecholamine stimulus reactive oxygen species metabolic process negative regulation of protein kinase activity dopamine receptor signaling pathway mating behavior visual learning negative regulation of cell migration positive regulation of cAMP biosynthetic process regulation of long-term neuronal synaptic plasticity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DRD5 Polyclonal Antibody

DRD5 Antibody (20310-1-AP) in IHC (P)

Product Details

20310-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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