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Product Details
PA5-118836
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DUSP22(Accession Q9NRW4), corresponding to amino acid residues D113-E163.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903336
Product Specific Information
Antibody detects endogenous levels of total DUSP22.
Target Information
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586F2224; Dual specificity protein phosphatase 22; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK pathway associated phosphatase; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP-1; LMW-DSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; mi; Mitogen-activated protein kinase phosphatase x; PYST2
Gene Aliases: DUSP22; JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2; MKP-x; MKPX; VHX
UniProt ID: (Human) Q9NRW4, (Mouse) Q99N11
Entrez Gene ID: (Human) 56940, (Mouse) 105352
negative regulation of transcription from RNA polymerase II promoter
inactivation of MAPK activity
negative regulation of T cell mediated immunity
protein dephosphorylation
apoptotic process
transforming growth factor beta receptor signaling pathway
multicellular organism development
cell proliferation
peptidyl-tyrosine dephosphorylation
regulation of cell proliferation
positive regulation of JNK cascade
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
dephosphorylation
Performance Guarantee
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