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Product Details
PA5-43680
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human DYNLL1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2608335
Product Specific Information
Peptide sequence: EKDIAAHIKK EFDKKYNPTW HCIVGRNFGS YVTHETKHFI YFYLGQVAIL
Sequence homology: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Target Information
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1, 200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; DLC1DNCLC1; DLC8; DLC8MGC126137; DNCL1MGC126138; Dynein light chain 1, cytoplasmic; Dynein light chain LC8-type 1; dynein, cytoplasmic, light polypeptide 1; dynein, light chain, LC8-type 1; H LC8; LC8-type 1; MGC126137; MGC126138; PIN; PINLC8a; Protein inhibitor of neuronal nitric oxide synthase
Gene Aliases: DLC1; DLC8; DNCL1; DNCLC1; DYNLL1; HDLC1; LC8; LC8a; PIN
UniProt ID: (Human) P63167
Entrez Gene ID: (Human) 8655
G2/M transition of mitotic cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
ER to Golgi vesicle-mediated transport
apoptotic process
female gamete generation
anatomical structure morphogenesis
viral process
macroautophagy
antigen processing and presentation of exogenous peptide antigen via MHC class II
substantia nigra development
actin cytoskeleton organization
intraciliary retrograde transport
negative regulation of phosphorylation
cilium morphogenesis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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