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DYRK2 Antibody (PA5-47734) in WB
Western blot analysis of DYRK2 in HeLa human cervical epithelial carcinoma cell line, Jurkat human acute T cell leukemia cell line, BaF3 mouse pro‚B cell line, C2C12 mouse myoblast cell line, and L6 rat myoblast cell line. Samples were incubated in DYRK2 polyclonal antibody (Product # PA5-47734) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. Specific bands were detected for DYRK2 at approximately 58 to 62 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47734
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human DYRK2 Met74-Glu180
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606268
Product Specific Information
This antibody detects endogenous human, mouse and rat DYRK2 in Western blots.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
DYRK2 (also known as dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2) belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development and is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 expressed in E. coli demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. DYRK2 also regulates p53 to induce apoptosis in response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dyrk2
Gene Aliases: 1810038L18Rik; DYRK2
UniProt ID: (Human) Q92630, (Mouse) Q5U4C9
Entrez Gene ID: (Human) 8445, (Mouse) 69181, (Rat) 314862
magnesium ion binding
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
manganese ion binding
ubiquitin binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
apoptotic process
smoothened signaling pathway
phosphorylation
peptidyl-tyrosine phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of glycogen biosynthetic process
negative regulation of NFAT protein import into nucleus
cellular response to DNA damage stimulus
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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