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Product Details
MUB0400P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chicken,
Hamster,
Human,
Mouse,
Pig,
Rabbit,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
RD301
Immunogen
Desmin
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
RD301 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CMD1I; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK
Gene Aliases: cb290; CSM1; CSM2; DES; desm; I79_018932; LGMD2R; wu:fb59a12; wu:fc11d08; zgc:109859; zgc:154009
UniProt ID: (Pig) P02540, (Dog) Q5XFN2, (Human) P17661, (Rat) P48675, (Mouse) P31001
muscle contraction
locomotory behavior
skeletal muscle organ development
intermediate filament organization
muscle organ development
intermediate filament polymerization
cytoskeleton organization
regulation of heart contraction
muscle filament sliding
skeletal muscle tissue development
regulation of cardiac muscle contraction by calcium ion signaling
myofibril assembly
sarcomere organization
regulation of cardiac muscle contraction
heart contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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