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NeoBiotechnologies
Desmocollin-2/3 Recombinant Mouse Monoclonal Antibody (DSC2/9165R)
Product Details
1824-RBM4-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
DSC2/9165R
Immunogen
Recombinant full-length human DSC2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:HeLa cells. Human esophagus or skin tissue.
Cellular Location: Cell surface
Target Information
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARVC10; ARVD10; Cadherin family member 2; Cadherin family member 3; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; Desmocollin-4; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; HT-CP
Gene Aliases: ARVD11; CDHF2; CDHF3; DG2; DGII/III; DSC; DSC1; DSC2; DSC3; DSC4; HT-CP
UniProt ID: (Human) Q02487, (Human) Q14574
Entrez Gene ID: (Human) 1824, (Human) 1825
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
cellular response to starvation
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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