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Drebrin Antibody (PA5-29346) in IHC (P)
Drebrin Polyclonal Antibody detects Drebrin protein at cytosol on rat hind brain by immunohistochemical analysis. Sample: Paraffin-embedded rat hind brain. Drebrin Polyclonal Antibody (Product # PA5-29346) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 401 and 596 of Human Drebrin
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546822
Product Specific Information
Recommended positive controls: SK-N-SH, IMR-32, SK-N-AS, NT2D1, IMR32, mouse brain, rat brain.
Predicted reactivity: Mouse (82%), Rat (81%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Developmentally-regulated brain protein; DKFZp434D064; Drebrin; drebrin A; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1; Drba
UniProt ID: (Human) Q16643, (Rat) Q07266, (Mouse) Q9QXS6
Entrez Gene ID: (Human) 1627, (Rat) 81653, (Mouse) 56320
actin filament organization
cell communication by chemical coupling
cell communication by electrical coupling
maintenance of protein location in cell
regulation of neuronal synaptic plasticity
regulation of dendrite development
neural precursor cell proliferation
cell-cell adhesion
nervous system development
generation of neurons
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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